Arylazopyrazole-Based Photoswitchable Inhibitors Selective for Escherichia coli Dihydrofolate Reductase.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00749
Abstract: Selective inhibitors of Escherichia coli dihydrofolate reductase (eDHFR) are crucial chemical biology tools that have widespread clinical applications. We developed a set of eDHFR-selective photoswitchable inhibitors by derivatizing the structure of our previously reported methotrexate… read more here.
Keywords: coli dihydrofolate; escherichia coli; photoswitchable inhibitors; biology ... See more keywords
Photoswitchable Inhibitors to Optically Control Specific Kinase Activity.
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DOI: 10.1021/acschembio.3c00119
Abstract: Potent and selective small-molecule inhibitors are valuable tools to elucidate the functions of protein kinases within complex signaling networks. Incorporation of a photoswitchable moiety into the inhibitor scaffold offers the opportunity to steer inhibitor potency… read more here.
Keywords: optically control; kinase; inhibitors optically; analog sensitive ... See more keywords
Reversible Photoswitchable Inhibitors Generate Ultrasensitivity in Out-of-Equilibrium Enzymatic Reactions
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c12956
Abstract: Ultrasensitivity is a ubiquitous emergent property of biochemical reaction networks. The design and construction of synthetic reaction networks exhibiting ultrasensitivity has been challenging, but would greatly expand the potential properties of life-like materials. Herein, we… read more here.
Keywords: generate ultrasensitivity; equilibrium enzymatic; inhibitors generate; reversible photoswitchable ... See more keywords