Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy.
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DOI: 10.1002/adma.202100595
Abstract: Pancreatic cancer, one of the most lethal malignancies, compromises the performance of traditional therapeutic regimens in the clinic because of stromal resistance to systemic drug delivery and poor prognosis caused by tumor metastasis. Therefore, a… read more here.
Keywords: photothermal immunotherapy; clinically approved; coassembly clinically; supramolecular nanofibrils ... See more keywords
A Facile, Protein‐Derived Supramolecular Theranostic Strategy for Multimodal‐Imaging‐Guided Photodynamic and Photothermal Immunotherapy In Vivo
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DOI: 10.1002/adma.202109111
Abstract: Theranostic systems that permit both diagnosis and treatment in vivo are highly appealing means by which to meet the demands of precision medicine. However, most such systems remain subject to issues related to complex molecular… read more here.
Keywords: vivo; supramolecular theranostic; strategy; photodynamic photothermal ... See more keywords
Glutathione‐Depleting Organic Metal Adjuvants for Effective NIR‐II Photothermal Immunotherapy
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DOI: 10.1002/adma.202201706
Abstract: Although photothermal immunotherapy (PTI) is a compelling strategy for tumor therapy, the development of promising photothermal agents to overcome the insufficient immunogenicity of tumor cells and the poor immune response encountered in PTI is still… read more here.
Keywords: photothermal immunotherapy; metal adjuvants; organic metal; glutathione ... See more keywords
Tailoring Multifunctional Small Molecular Photosensitizers to In Vivo Self-Assemble with Albumin to Boost Tumor-Preferential Accumulation, NIR Imaging, and Photodynamic/Photothermal/Immunotherapy.
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DOI: 10.1002/smll.202201298
Abstract: Cancer immunotherapy has great potential in tumor eradication and metastasis suppression. However, systemic administration of immune adjuvants and inadequate specificity in cancer treatment, lead to restricted therapeutic benefits and potential immune-related side effects in clinical… read more here.
Keywords: immunotherapy; imaging photodynamic; accumulation; photodynamic photothermal ... See more keywords
Janus‐like BxC/C Quantum Sheets with Z‐Scheme Mechanism Strengthen Tumor Photothermal‐Immunotherapy in NIR‐II Biowindow
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DOI: 10.1002/smtd.202101551
Abstract: Carbon dots (CDs) are one of the most popular photothermal agents (PTAs) as a noninvasive strategy for tumor treatment. However, because of the inherent dominant fluorescent emission, the CDs‐based PTAs hardly achieve a single photothermal… read more here.
Keywords: bxc; quantum sheets; conversion; photothermal immunotherapy ... See more keywords
Gold Nanorods and Polymer Micelles Mediated Dual TLR Stimulators Delivery System CPG@Au NRs/M‐R848 Regulate Macrophages Reprogramming and DC Maturation for Enhanced Photothermal Immunotherapy of Melanoma
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DOI: 10.1002/smtd.202201087
Abstract: Synergistic photothermal immunotherapy has emerged as a favorable therapeutic approach to fight cancer. However, design of an effective photothermal immunotherapy system to suppress tumor growth and simultaneously inhibit tumor metastases continues to be a challenge.… read more here.
Keywords: nrs r848; system; immunotherapy; cpg nrs ... See more keywords
Activatable Immunoprotease Nanorestimulator for Second Near-Infrared Photothermal Immunotherapy of Cancer.
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DOI: 10.1021/acsnano.2c12066
Abstract: Photothermal immunotherapy is a combinational cancer therapy modality, wherein the photothermal process can noninvasively ablate cancer and efficiently trigger cancer immunogenic cell death to ignite antitumor immunity. However, cancer cells can resist the cytotoxic lymphocyte-mediated… read more here.
Keywords: second near; near infrared; immunoprotease; photothermal immunotherapy ... See more keywords
Combined photothermal-immunotherapy via poly-tannic acid coated PLGA nanoparticles for cancer treatment.
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DOI: 10.1039/d1bm00474c
Abstract: Photothermal therapy (PTT) is able to ablate tumors via hyperthermia, while immunotherapy could prevent tumor recurrence and metastasis by activating the host immune responses. Therefore, the combination of PTT and immunotherapy offers great advantages for… read more here.
Keywords: photothermal immunotherapy; combined photothermal; immunotherapy; coated plga ... See more keywords
IR792-MCN@ZIF-8-PD-L1 siRNA drug delivery system enhances photothermal immunotherapy for triple-negative breast cancer under near-infrared laser irradiation
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DOI: 10.1186/s12951-022-01255-6
Abstract: Background Despite extensive investigations on photothermal therapy, the clinical application is restricted due to poor stability, low therapeutic efficacy of photothermal therapy agents and its affinity loss in the multistep synthesis of delivery carriers. To… read more here.
Keywords: laser; delivery; delivery system; irradiation ... See more keywords