Triarylboron‐Doped Acenethiophenes as Organic Sonosensitizers for Highly Efficient Sonodynamic Therapy with Low Phototoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202206594
Abstract: The development of efficient organic sonosensitizers is crucial for sonodynamic therapy (SDT) in the field of cancer treatment. Herein, a new strategy for the development of efficient organic sonosensitizers based on triarylboron‐doped acenethiophene scaffolds is… read more here.
Keywords: organic sonosensitizers; phototoxicity; doped acenethiophenes; low phototoxicity ... See more keywords
A critical review of polycyclic aromatic hydrocarbon phototoxicity models.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.3722
Abstract: Polycyclic aromatic hydrocarbons (PAHs) are known to exhibit photo-induced toxicity. Hundreds to thousands of PAH parent and substituted compounds are found in the environment, and developing a predictive model applicable to a wide variety of… read more here.
Keywords: aromatic hydrocarbon; review polycyclic; polycyclic aromatic; phototoxicity ... See more keywords
Predicting phototoxicity of alkylated PAHs, mixtures of PAHs, and water accommodated fractions (WAF) of neat and weathered petroleum with the phototoxic target lipid model.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.4173
Abstract: The toxicity of petroleum can increase considerably after exposure to solar radiation, during which certain components in the mixture, including polycyclic aromatic hydrocarbons (PAHs), absorb light in ultraviolet and visible portions of the solar radiation… read more here.
Keywords: alkylated pahs; target lipid; phototoxic target; lipid model ... See more keywords
Decreased phototoxicity of photodynamic therapy by Cx32/Cx26‐composed GJIC: A “Good Samaritan” effect
Sign Up to like & getrecommendations! Published in 2019 at "Lasers in Surgery and Medicine"
DOI: 10.1002/lsm.23044
Abstract: Photodynamic therapy (PDT) has been widely used to treat malignant tumors. Our previous studies indicated that connexin (Cx) 32‐ and Cx26‐composed gap junctional intercellular communication (GJIC) could improve the phototoxicity of PDT. However, the role… read more here.
Keywords: cx26 composed; photodynamic therapy; cx32 cx26; cx26 ... See more keywords
Evaluation of the skin phototoxicity of systemically administered pharmaceuticals in Sprague-Dawley rats.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicological research"
DOI: 10.1007/s43188-020-00078-7
Abstract: In vivo phototoxicity testing is important for predicting drug-induced phototoxicity in humans. Currently, there is no internationally validated in vivo test method for the photosafety evaluation of pharmaceuticals. In this study, we evaluated the phototoxicity… read more here.
Keywords: systemically administered; evaluation; phototoxicity; phototoxicity systemically ... See more keywords
Computational Investigation of Drug Phototoxicity: Photosafety Assessment, Photo-Toxophore Identification and Machine Learning.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00338
Abstract: One of the most appreciated capabilities of computational toxicology is to support the design of pharmaceuticals with reduced toxicological hazard. To this end, we have strengthened our drug photosafety assessments by applying novel computer models… read more here.
Keywords: machine learning; drug; phototoxicity; photosafety ... See more keywords
Acid-Induced Intracellular Dissociation of β-Cyclodextrin-Threaded Polyrotaxanes Directed toward Attenuating Phototoxicity of Bisretinoids through Promoting Excretion.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00859
Abstract: In the retinal pigment epithelium of patients with age-related macular degeneration (AMD), excess N-retinylidene-N-retinylethanolamine (A2E), a dimer of all-trans-retinal, accumulats to induce inflammatory cytokine secretion and phototoxic effects. Therefore, the reduction of intracellular A2E is… read more here.
Keywords: threaded polyrotaxanes; cyclodextrin threaded; acid labile; prxs ... See more keywords
Acceptor engineering of metallacycles with high phototoxicity indices for safe and effective photodynamic therapy
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc06936a
Abstract: Although metallacycle-based photosensitizers have attracted increasing attention in biomedicine, their clinical application has been hindered by their inherent dark toxicity and unsatisfactory phototherapeutic efficiency. Herein, we employ a π-expansion strategy for ruthenium acceptors to develop… read more here.
Keywords: engineering metallacycles; phototoxicity; metallacycles high; acceptor engineering ... See more keywords
In vitro phototoxicity of rhodopsin photobleaching products in the retinal pigment epithelium (RPE)
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Research"
DOI: 10.1080/10715762.2019.1603377
Abstract: Abstract Although the primary biological function of retinal photoreceptors is to absorb light and provide visual information, extensive exposure to intense light could increase the risk of phototoxic reactions mediated by products of rhodopsin bleaching… read more here.
Keywords: pos; light; pigment epithelium; photobleaching products ... See more keywords
Phototoxicity and cell passage affect intracellular reactive oxygen species levels and sensitivity towards non-thermal plasma treatment in fluorescently-labeled cancer cells
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Physics D: Applied Physics"
DOI: 10.1088/1361-6463/accc3d
Abstract: Live-cell imaging with fluorescence microscopy is a powerful tool, especially in cancer research, widely-used for capturing dynamic cellular processes over time. However, light-induced toxicity (phototoxicity) can be incurred from this method, via disruption of intracellular… read more here.
Keywords: reactive oxygen; thermal plasma; oxygen species; phototoxicity ... See more keywords
Nutraceutical Strategies for Alleviation of UVB Phototoxicity.
Sign Up to like & getrecommendations! Published in 2023 at "Experimental dermatology"
DOI: 10.1111/exd.14777
Abstract: Ultraviolet B exposure to keratinocytes promotes carcinogenesis by inducing pyrimidine dimer lesions in DNA, suppressing the nucleotide excision repair mechanism required to fix them, inhibiting the apoptosis required for the elimination of initiated cells, and… read more here.
Keywords: alleviation uvb; phototoxicity; dermatology; strategies alleviation ... See more keywords