Targeting NOX2 via p47/phox-p22/phox Inhibition with Novel Triproline Mimetics.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00094
Abstract: On the basis of the knowledge that the proline-rich hot spot PPPRPP region of P(151)PSNPPPRPP(160), an oligopeptide derived from the cytosolic portion of p22phox (p22), binds to the single functional bis-SH3 domain of the regulatory… read more here.
Keywords: phox; triproline; p47; targeting nox2 ... See more keywords
The downregulation of NADPH oxidase Nox4 during hypoxia in hemangioendothelioma cells: a possible role of p22 phox on Nox4 protein stability
Sign Up to like & getrecommendations! Published in 2022 at "Free Radical Research"
DOI: 10.1080/10715762.2021.2009116
Abstract: Abstract NADPH oxidase (Nox) 4 produces H2O2 by forming a heterodimer with p22 phox and is involved in hemangioendothelioma development through monocyte chemoattractant protein-1 (MCP-1) upregulation. Here, we show that Nox4 protein levels were maintained… read more here.
Keywords: p22 phox; phox; nox4 protein; hemangioendothelioma cells ... See more keywords
Chalcone skeleton promotes transcription of gp91‐phox gene but inhibits expression of gp91‐phox protein, and hydroxyl groups in hydroxychalcones participate in the stable expression of gp91‐phox protein
Sign Up to like & getrecommendations! Published in 2019 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12732
Abstract: The effects of chalcone and butein on the induction of the superoxide anion (O2‐)‐generating system were studied in U937 cells by all‐trans retinoic acid (RA). The chalcone skeleton, a common structural motif in them, significantly… read more here.
Keywords: phox; expression gp91; phox protein; gp91 phox ... See more keywords
Potential role of green tea amino acid l‐theanine in the activation of innate immune response by enhancing expression of cytochrome b558 responsible for the reactive oxygen species‐generating ability of leukocytes
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12977
Abstract: l‐Theanine (N‐ethyl‐ l‐glutamine) is an analog of l‐glutamine and l‐glutamic acid, accounts for up to 50% of all free amino acids in green tea, and elicits an umami taste. As l‐theanine also shows various physiological… read more here.
Keywords: phox; theanine; immune response; cytochrome b558 ... See more keywords
NOX Activation by Subunit Interaction and Underlying Mechanisms in Disease
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2016.00301
Abstract: Nicotinamide adenine dinucleotide phosphate (NAPDH) oxidase (NOX) is an enzyme complex with the sole function of producing superoxide anion and reactive oxygen species (ROS) at the expense of NADPH. Vital to the immune system as… read more here.
Keywords: p22 phox; nox; activation; interaction ... See more keywords
NADPH Oxidase Isoform 2 (NOX2) Is Involved in Drug Addiction Vulnerability in Progeny Developmentally Exposed to Ethanol
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2017.00338
Abstract: Ethanol exposure increases oxidative stress in developing organs, including the brain. Antioxidant treatment during maternal ethanol ingestion improves behavioral deficits in rodent models of fetal alcohol spectrum disorder (FASD). However, the impact of general antioxidant… read more here.
Keywords: p70; expression; ethanol; phox ... See more keywords