Prevalence and Risk of Vertebral Fractures in Primary Hyperparathyroidism: A Nested Case‐Control Study
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DOI: 10.1002/jbmr.3461
Abstract: Prevalence of vertebral fractures (VFx) in primary hyperparathyroidism (PHPT) remains uncertain. We aimed to estimate the prevalence of VFx, investigate potential risk factors associated with VFx, and whether bone mineral density (BMD) differs between PHPT… read more here.
Keywords: risk; primary hyperparathyroidism; prevalence; phpt ... See more keywords
Surgical Aspects of Primary Hyperparathyroidism
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DOI: 10.1002/jbmr.4689
Abstract: Parathyroidectomy (PTX) is the treatment of choice for symptomatic primary hyperparathyroidism (PHPT). It is also the treatment of choice in asymptomatic PHPT with evidence for target organ involvement. This review updates surgical aspects of PHPT… read more here.
Keywords: surgical aspects; phpt; ptx; primary hyperparathyroidism ... See more keywords
Current opinions on nephrolithiasis associated with primary hyperparathyroidism
Sign Up to like & getrecommendations! Published in 2018 at "Urolithiasis"
DOI: 10.1007/s00240-018-1038-x
Abstract: Nephrolithiasis is a common urological disease and could be secondary to primary hyperparathyroidism (PHPT). PHPT is traditionally characterised with hypercalcaemia. Recently, a normocalcemic PHPT has been officially recognised at the International Workshops. Regarding this new… read more here.
Keywords: primary hyperparathyroidism; nephrolithiasis associated; phpt; nephrolithiasis ... See more keywords
The Significance of Histologically “Large Normal” Parathyroid Glands in Primary Hyperparathyroidism
Sign Up to like & getrecommendations! Published in 2019 at "World Journal of Surgery"
DOI: 10.1007/s00268-019-05302-6
Abstract: Introduction We investigated outcomes in a cohort of patients with a biochemical diagnosis of primary hyperparathyroidism (pHPT) undergoing surgery for asymptomatic disease or target organ damage, where a focussed or four-gland operation was undertaken and… read more here.
Keywords: large normal; primary hyperparathyroidism; lnp; phpt ... See more keywords
Single Gland, Ectopic Location: Adenomas are Common Causes of Primary Hyperparathyroidism in Children and Adolescents
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DOI: 10.1007/s00268-019-05362-8
Abstract: Background Primary hyperparathyroidism (PHPT) in children and adolescents is uncommon. Data-driven guidelines for management in pediatric patients are limited. Methods We performed a retrospective cohort analysis of all patients (1997–2017) with PHPT ≤ 21 years of age who… read more here.
Keywords: primary hyperparathyroidism; adenomas; phpt; children adolescents ... See more keywords
Impaired calcium sensing distinguishes primary hyperparathyroidism (PHPT) patients with low bone mineral density.
Sign Up to like & getrecommendations! Published in 2017 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2017.06.004
Abstract: CONTEXT A subset of PHPT patients exhibit a more severe disease phenotype characterized by bone loss, fractures, recurrent nephrolithiasis, and other dysfunctions, but the underlying reasons for this disparity in clinical presentation remain unknown. OBJECTIVE… read more here.
Keywords: ec50; bone mineral; phpt; mineral density ... See more keywords
Bone disease in primary hyperparathyroidism.
Sign Up to like & getrecommendations! Published in 2018 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2017.10.003
Abstract: Primary hyperparathyroidism (PHPT) is a disease of high bone turnover, decreased bone mineral density (BMD) especially at cortical sites, and increased risk of fractures at all skeletal sites. Early diagnosis during the last decades resulted… read more here.
Keywords: bone; bone disease; primary hyperparathyroidism; phpt ... See more keywords
Primary hyperparathyroidism: should surgery be performed on all patients? Current evidence and residual uncertainties
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Internal Medicine"
DOI: 10.1111/joim.12840
Abstract: Primary hyperparathyroidism (pHPT) is the third most common endocrine disease and is characterized by hypercalcaemia and elevated or inappropriately ‘normal’ levels of the parathyroid hormone (PTH). The main target organs of PTH are the skeletal… read more here.
Keywords: hyperparathyroidism; primary hyperparathyroidism; hyperparathyroidism surgery; treatment ... See more keywords
A garden of parathyroid adenomas
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DOI: 10.1136/bcr-2017-221130
Abstract: Despite improvements in parathyroidectomy success rates, patients with persistent primary hyperparathyroidism (PHPT) after initial surgery continue to challenge clinicians. Some of the challenges are due to ectopic parathyroid adenomas, including thymic, intrathyroidal, carotid sheath and… read more here.
Keywords: parathyroid adenomas; phpt; garden parathyroid; adenomas ... See more keywords
Gout in Primary Hyperparathyroidism, Connecting Crystals to the Minerals
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DOI: 10.1210/jendso/bvac018
Abstract: Abstract Musculoskeletal manifestations in primary hyperparathyroidism (PHPT) range from 13% to 93% encompassing pseudogout, vertebral fracture, myopathy, and cord compression. Though pseudogout has been the most prevalent musculoskeletal condition in PHPT, rarely reports of acute… read more here.
Keywords: phpt; connecting crystals; primary hyperparathyroidism; hyperparathyroidism connecting ... See more keywords
Parathyroid Hormone Regulates Circulating Levels of Sclerostin and FGF23 in a Primary Hyperparathyroidism Model
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DOI: 10.1210/jendso/bvac027
Abstract: Abstract Parathyroid hormone (PTH) increases fibroblast growth factor 23 (FGF23), mediated both by protein kinase A (PKA) and Wnt signaling, and decreases expression of sclerostin, a Wnt antagonist derived from osteocytes. Patients with primary hyperparathyroidism… read more here.
Keywords: fgf23; phpt; primary hyperparathyroidism; sclerostin ... See more keywords