Prevalence and Risk of Vertebral Fractures in Primary Hyperparathyroidism: A Nested Case‐Control Study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3461
Abstract: Prevalence of vertebral fractures (VFx) in primary hyperparathyroidism (PHPT) remains uncertain. We aimed to estimate the prevalence of VFx, investigate potential risk factors associated with VFx, and whether bone mineral density (BMD) differs between PHPT… read more here.
Keywords: risk; primary hyperparathyroidism; prevalence; phpt ... See more keywords
Surgical Aspects of Primary Hyperparathyroidism
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4689
Abstract: Parathyroidectomy (PTX) is the treatment of choice for symptomatic primary hyperparathyroidism (PHPT). It is also the treatment of choice in asymptomatic PHPT with evidence for target organ involvement. This review updates surgical aspects of PHPT… read more here.
Keywords: surgical aspects; phpt; ptx; primary hyperparathyroidism ... See more keywords
Current opinions on nephrolithiasis associated with primary hyperparathyroidism
Sign Up to like & getrecommendations! Published in 2018 at "Urolithiasis"
DOI: 10.1007/s00240-018-1038-x
Abstract: Nephrolithiasis is a common urological disease and could be secondary to primary hyperparathyroidism (PHPT). PHPT is traditionally characterised with hypercalcaemia. Recently, a normocalcemic PHPT has been officially recognised at the International Workshops. Regarding this new… read more here.
Keywords: primary hyperparathyroidism; nephrolithiasis associated; phpt; nephrolithiasis ... See more keywords
The Significance of Histologically “Large Normal” Parathyroid Glands in Primary Hyperparathyroidism
Sign Up to like & getrecommendations! Published in 2019 at "World Journal of Surgery"
DOI: 10.1007/s00268-019-05302-6
Abstract: Introduction We investigated outcomes in a cohort of patients with a biochemical diagnosis of primary hyperparathyroidism (pHPT) undergoing surgery for asymptomatic disease or target organ damage, where a focussed or four-gland operation was undertaken and… read more here.
Keywords: large normal; primary hyperparathyroidism; lnp; phpt ... See more keywords
Single Gland, Ectopic Location: Adenomas are Common Causes of Primary Hyperparathyroidism in Children and Adolescents
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Surgery"
DOI: 10.1007/s00268-019-05362-8
Abstract: Background Primary hyperparathyroidism (PHPT) in children and adolescents is uncommon. Data-driven guidelines for management in pediatric patients are limited. Methods We performed a retrospective cohort analysis of all patients (1997–2017) with PHPT ≤ 21 years of age who… read more here.
Keywords: primary hyperparathyroidism; adenomas; phpt; children adolescents ... See more keywords
Normocalcemic primary hyperparathyroidism is not associated with cardiometabolic alterations
Sign Up to like & getrecommendations! Published in 2024 at "Endocrine"
DOI: 10.1007/s12020-024-04063-0
Abstract: Cardiometabolic disorders are non-classical complications of hypercalcemic primary hyperparathyroidism (HC-PHPT), but whether this risk connotes normocalcemic PHPT (NC-PHPT) remains to be elucidated. We investigated cardiometabolic alterations in both forms of PHPT, looking for their association… read more here.
Keywords: primary hyperparathyroidism; phpt; cardiometabolic alterations; phpt phpt ... See more keywords
Impaired calcium sensing distinguishes primary hyperparathyroidism (PHPT) patients with low bone mineral density.
Sign Up to like & getrecommendations! Published in 2017 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2017.06.004
Abstract: CONTEXT A subset of PHPT patients exhibit a more severe disease phenotype characterized by bone loss, fractures, recurrent nephrolithiasis, and other dysfunctions, but the underlying reasons for this disparity in clinical presentation remain unknown. OBJECTIVE… read more here.
Keywords: ec50; bone mineral; phpt; mineral density ... See more keywords
Bone disease in primary hyperparathyroidism.
Sign Up to like & getrecommendations! Published in 2018 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2017.10.003
Abstract: Primary hyperparathyroidism (PHPT) is a disease of high bone turnover, decreased bone mineral density (BMD) especially at cortical sites, and increased risk of fractures at all skeletal sites. Early diagnosis during the last decades resulted… read more here.
Keywords: bone; bone disease; primary hyperparathyroidism; phpt ... See more keywords
mRNA expression of vitamin D receptor, calcium-sensing receptor, cyclin D1, and PTH in symptomatic and asymptomatic primary hyperparathyroidism.
Sign Up to like & getrecommendations! Published in 2024 at "European journal of endocrinology"
DOI: 10.1093/ejendo/lvae122
Abstract: BACKGROUND AND OBJECTIVE The exact underlying mechanism for the differential clinical profiles of symptomatic and asymptomatic primary hyperparathyroidism (PHPT) patients has not been fully elucidated, and efforts to define the molecular mechanisms underlying the phenotypic… read more here.
Keywords: symptomatic asymptomatic; receptor; phpt; phpt patients ... See more keywords
Autosomal dominant primary hyperparathyroidism in the Keeshond dog breed is strongly associated with a missense variant in sirtuin-6.
Sign Up to like & getrecommendations! Published in 2025 at "Animal genetics"
DOI: 10.1111/age.70056
Abstract: Primary hyperparathyroidism (PHPT) is an inherited disorder that leads to inappropriate secretion of parathyroid hormone by neoplastic parathyroid cells. Dogs of the Keeshond breed are predisposed to adenomas or hyperplasia of the parathyroid that lead… read more here.
Keywords: primary hyperparathyroidism; dog; phpt; variant ... See more keywords
Primary hyperparathyroidism: should surgery be performed on all patients? Current evidence and residual uncertainties
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Internal Medicine"
DOI: 10.1111/joim.12840
Abstract: Primary hyperparathyroidism (pHPT) is the third most common endocrine disease and is characterized by hypercalcaemia and elevated or inappropriately ‘normal’ levels of the parathyroid hormone (PTH). The main target organs of PTH are the skeletal… read more here.
Keywords: hyperparathyroidism; primary hyperparathyroidism; hyperparathyroidism surgery; treatment ... See more keywords