PHPT1 acts as an inhibitor in high-altitude pulmonary hypertension via negative TRPV5 signaling regulation
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DOI: 10.1186/s12967-025-06980-8
Abstract: Low barometric pressure hypoxia at high altitudes triggers vascular remodeling, resulting in high-altitude pulmonary hypertension (HAPH). The key step is the transformation of pulmonary artery smooth muscle cells (PASMCs) from a contractile to synthetic phenotype.… read more here.
Keywords: phpt1; high altitude; altitude pulmonary; pulmonary hypertension ... See more keywords