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   Articles with "phrenic motor" as a keyword



Microglia regulate motor neuron plasticity via reciprocal fractalkine and adenosine signaling

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-54619-x

Abstract: We report an important role for microglia in regulating neuroplasticity within phrenic motor neurons. Brief episodes of low oxygen (acute intermittent hypoxia; AIH) elicit a form of respiratory motor plasticity known as phrenic long-term facilitation… read more here.

Keywords: motor neuron; fractalkine; adenosine; plasticity ... See more keywords

Anatomical Recruitment of Spinal V2a Interneurons into Phrenic Motor Circuitry after High Cervical Spinal Cord Injury.

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recommendations! Published in 2017 at "Journal of neurotrauma"

DOI: 10.1089/neu.2017.5045

Abstract: More than half of all spinal cord injuries (SCIs) occur at the cervical level, often resulting in impaired respiration. Despite this devastating outcome, there is substantial evidence for endogenous neuroplasticity after cervical SCI. Spinal interneurons… read more here.

Keywords: high cervical; v2a interneurons; spinal cord; phrenic motor ... See more keywords

Inactivity-induced phrenic motor facilitation requires PKCζ activity within phrenic motor neurons.

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recommendations! Published in 2024 at "Journal of neurophysiology"

DOI: 10.1152/jn.00138.2024

Abstract: Prolonged inhibition of respiratory neural activity elicits a long-lasting increase in phrenic nerve amplitude, known as inactivity-induced phrenic motor facilitation (iPMF). Facilitation also occurs transiently in inspiratory intercostal nerve activity following inactivity (iIMF). Atypical PKC… read more here.

Keywords: inactivity; pkc; phrenic motor; motor ... See more keywords

BDNF-induced Phrenic Motor Facilitation Shifts from PKCΘ to ERK-Dependence With Mild Systemic Inflammation.

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recommendations! Published in 2023 at "Journal of neurophysiology"

DOI: 10.1152/jn.00345.2022

Abstract: Moderate acute intermittent hypoxia (mAIH) elicits a form of phrenic motor plasticity known as phrenic long-term facilitation (pLTF) which requires spinal 5-HT2A receptor activation, ERK/MAP kinase signaling and BDNF synthesis. New BDNF protein activates TrkB… read more here.

Keywords: phrenic motor; inflammation; bdnf induced; bdnf ... See more keywords

Spinal NMDA receptor activation is necessary to initiate but not maintain ampakine-hypoxia induced phrenic motor facilitation

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5732375

Abstract: Ampakines are a class of compounds which act as positive allosteric modulators of AMPA receptors. Intravenous (i.v.) delivery of a “low impact” ampakine prior to a single brief hypoxic episode produces a persistent (≥60 min)… read more here.

Keywords: nmda receptor; phrenic motor; physiology; receptor activation ... See more keywords