Anatomical Recruitment of Spinal V2a Interneurons into Phrenic Motor Circuitry after High Cervical Spinal Cord Injury.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of neurotrauma"
DOI: 10.1089/neu.2017.5045
Abstract: More than half of all spinal cord injuries (SCIs) occur at the cervical level, often resulting in impaired respiration. Despite this devastating outcome, there is substantial evidence for endogenous neuroplasticity after cervical SCI. Spinal interneurons… read more here.
Keywords: high cervical; v2a interneurons; spinal cord; phrenic motor ... See more keywords
BDNF-induced Phrenic Motor Facilitation Shifts from PKCΘ to ERK-Dependence With Mild Systemic Inflammation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurophysiology"
DOI: 10.1152/jn.00345.2022
Abstract: Moderate acute intermittent hypoxia (mAIH) elicits a form of phrenic motor plasticity known as phrenic long-term facilitation (pLTF) which requires spinal 5-HT2A receptor activation, ERK/MAP kinase signaling and BDNF synthesis. New BDNF protein activates TrkB… read more here.
Keywords: phrenic motor; inflammation; bdnf induced; bdnf ... See more keywords
Spinal NMDA receptor activation is necessary to initiate but not maintain ampakine-hypoxia induced phrenic motor facilitation
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732375
Abstract: Ampakines are a class of compounds which act as positive allosteric modulators of AMPA receptors. Intravenous (i.v.) delivery of a “low impact” ampakine prior to a single brief hypoxic episode produces a persistent (≥60 min)… read more here.
Keywords: nmda receptor; phrenic motor; physiology; receptor activation ... See more keywords