Synthesis, molecular docking and biological evaluation of novel phthaloyl derivatives of 3-amino-3-aryl propionic acids as inhibitors of Trypanosoma cruzi trans-sialidase.
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DOI: 10.1016/j.ejmech.2018.07.005
Abstract: In the last two decades, trans-sialidase of Trypanosoma cruzi (TcTS) has been an important pharmacological target for developing new anti-Chagas agents. In a continuous effort to discover new potential TcTS inhibitors, 3-amino-3-arylpropionic acid derivatives (series… read more here.
Keywords: phthaloyl derivatives; trans sialidase; novel phthaloyl; trypanosoma cruzi ... See more keywords