CCL5 confines liver regeneration by downregulating reparative macrophage-derived HGF in an FoxO3a dependent manner.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32458
Abstract: BACKGROUND AND AIMS Liver regeneration is vital for the recovery of liver function after hepatectomy. Limited regeneration capacity together with insufficient remnant liver volume is a risk factor for post-hepatectomy liver failure resulting from small-for-size… read more here.
Keywords: liver regeneration; hepatectomy; phx; ccl5 ... See more keywords
Dexmedetomidine promotes liver regeneration in mice after 70% partial hepatectomy by suppressing NLRP3 inflammasome not TLR4/NF&kgr;B
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.10.030
Abstract: ABSTRACT Inflammasome activation is mediated by NOD‐like receptors (NLRs) that play important role in cellular proliferation. NLRP3 senses the widest array of stimuli. But its role in the liver regeneration after partial hepatectomy (PHx) is… read more here.
Keywords: phx; liver regeneration; tlr4 kgr; dex ... See more keywords
Interplay between liver circadian rhythm and regeneration after PHx.
Sign Up to like & getrecommendations! Published in 2021 at "Genomics"
DOI: 10.1016/j.ygeno.2021.11.023
Abstract: Diurnal oscillations in gene expression are a hallmark of the liver internal clock and can be regulated by a variety of environmental stimuli. The circadian rhythm and liver regeneration (LR) are intimately linked. However, how… read more here.
Keywords: phx; interplay liver; rhythm; regeneration ... See more keywords
Proteomic characterisation of perhexiline treatment on THP-1 M1 macrophage differentiation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1054588
Abstract: Background Dysregulated inflammation is important in the pathogenesis of many diseases including cancer, allergy, and autoimmunity. Macrophage activation and polarisation are commonly involved in the initiation, maintenance and resolution of inflammation. Perhexiline (PHX), an antianginal… read more here.
Keywords: thp macrophage; phx; perhexiline; differentiation ... See more keywords
F4/80+ Kupffer Cell-Derived Oncostatin M Sustains the Progression Phase of Liver Regeneration through Inhibition of TGF-β2 Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26082231
Abstract: The role of Kupffer cells (KCs) in liver regeneration is complicated and controversial. To investigate the distinct role of F4/80+ KCs at the different stages of the regeneration process, two-thirds partial hepatectomy (PHx) was performed… read more here.
Keywords: phx; phase; liver regeneration; regeneration ... See more keywords