Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2022 at "Genome Research"
DOI: 10.1101/gr.276515.121
Abstract: Aging is associated with changes in a variety of biological processes at the transcriptomic level, including gene expression. Two types of aging occur during a lifetime: chronological and physiological aging. However, dissecting the difference between… read more here.
Keywords: physiological aging; chronological aging; associated physiological; physiological chronological ... See more keywords
Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn4437
Abstract: Aging is a prominent risk factor for neurodegenerative disorders (NDDs); however, the molecular mechanisms rendering the aged brain particularly susceptible to neurodegeneration remain unclear. Here, we aim to determine the link between physiological aging and… read more here.
Keywords: physiological aging; aged brains; adaptation; neurodegeneration ... See more keywords
Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty.
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DOI: 10.1152/physiol.00012.2016
Abstract: Advancing age is associated with progressive declines in physiological function that lead to overt chronic disease, frailty, and eventual mortality. Importantly, age-related physiological changes occur in cellularity, insulin-responsiveness, secretory profiles, and inflammatory status of adipose… read more here.
Keywords: tissue dysfunction; age; tissue; physiological aging ... See more keywords
Physiological aging around the World
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DOI: 10.1371/journal.pone.0268276
Abstract: We extract data on physiological aging by computing a frailty index for 201 countries over the period 1990–2019. Using panel estimation techniques, we show that the macro frailty index replicates basic regularities previously observed in… read more here.
Keywords: physiological aging; frailty index; around world; aging around ... See more keywords