Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS
Sign Up to like & getrecommendations! Published in 2024 at "Acta Neuropathologica"
DOI: 10.1007/s00401-024-02733-x
Abstract: Aging affects all cell types in the CNS and plays an important role in CNS diseases. However, the underlying molecular mechanisms driving these age-associated changes and their contribution to diseases are only poorly understood. The… read more here.
Keywords: inflammation induced; age; white matter; cellular senescence ... See more keywords
Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2022 at "Genome Research"
DOI: 10.1101/gr.276515.121
Abstract: Aging is associated with changes in a variety of biological processes at the transcriptomic level, including gene expression. Two types of aging occur during a lifetime: chronological and physiological aging. However, dissecting the difference between… read more here.
Keywords: physiological aging; chronological aging; associated physiological; physiological chronological ... See more keywords
Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn4437
Abstract: Aging is a prominent risk factor for neurodegenerative disorders (NDDs); however, the molecular mechanisms rendering the aged brain particularly susceptible to neurodegeneration remain unclear. Here, we aim to determine the link between physiological aging and… read more here.
Keywords: physiological aging; aged brains; adaptation; neurodegeneration ... See more keywords
Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty.
Sign Up to like & getrecommendations! Published in 2017 at "Physiology"
DOI: 10.1152/physiol.00012.2016
Abstract: Advancing age is associated with progressive declines in physiological function that lead to overt chronic disease, frailty, and eventual mortality. Importantly, age-related physiological changes occur in cellularity, insulin-responsiveness, secretory profiles, and inflammatory status of adipose… read more here.
Keywords: tissue dysfunction; age; tissue; physiological aging ... See more keywords
Physiological aging around the World
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0268276
Abstract: We extract data on physiological aging by computing a frailty index for 201 countries over the period 1990–2019. Using panel estimation techniques, we show that the macro frailty index replicates basic regularities previously observed in… read more here.
Keywords: physiological aging; frailty index; around world; aging around ... See more keywords
Physiological Aging under Commercial Conditions Enhances Performance of Three Potato (Solanum tuberosum L.) Cultivars
Sign Up to like & getrecommendations! Published in 2025 at "HortTechnology"
DOI: 10.21273/horttech05711-25
Abstract: The physiological age of potato (Solanum tuberosum L.) seed tubers influences emergence, apical dominance, tuber set, and size distribution, all of which are traits that affect crop value. While prior studies have examined storage and… read more here.
Keywords: physiological aging; seed; potato solanum; solanum tuberosum ... See more keywords