Molecular mechanisms and physiological relevance of RGK proteins in the heart
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DOI: 10.1111/apha.13016
Abstract: The primary route of Ca2+ entry into cardiac myocytes is via 1,4‐dihydropyridine‐sensitive, voltage‐gated L‐type Ca2+ channels. Ca2+ influx through these channels influences duration of action potential and engages excitation‐contraction (EC) coupling in both the atria… read more here.
Keywords: mechanisms physiological; heart; rgk; physiological relevance ... See more keywords
Improving physiological relevance of cell culture: the possibilities, considerations, and future directions of the ex vivo coculture model
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DOI: 10.1152/ajpcell.00473.2022
Abstract: In vitro models provide an important platform for the investigation of cellular growth and atrophy to inform, or extend mechanistic insights from, logistically challenging in vivo trials. While these models allow for the identification of… read more here.
Keywords: improving physiological; cell; future directions; physiology ... See more keywords
Neprilysin 4: an essential peptidase with multifaceted physiological relevance
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DOI: 10.1515/hsz-2022-0286
Abstract: Abstract Neprilysins are highly conserved ectoenzymes that hydrolyze and thus inactivate signaling peptides in the extracellular space. Herein, we focus on Neprilysin 4 from Drosophila melanogaster and evaluate the existing knowledge on the physiological relevance… read more here.
Keywords: neprilysin essential; peptidase; neprilysin; essential peptidase ... See more keywords