Cellular and physiological roles of the conserved atypical MAP kinase ERK7
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14521
Abstract: Extracellular signal‐regulated kinase 7 (ERK7), also known as ERK8 and MAPK15, is an atypical member of the MAP kinase family. Compared with other MAP kinases, the biological roles of ERK7 remain poorly understood. Recent work,… read more here.
Keywords: map; physiological roles; cellular physiological; kinase erk7 ... See more keywords
C‐type lectin receptors of the Dectin‐1 cluster: Physiological roles and involvement in disease
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847536
Abstract: C‐type lectin receptors (CLRs) are essential for multicellular existence, having diverse functions ranging from embryonic development to immune function. One subgroup of CLRs is the Dectin‐1 cluster, comprising of seven receptors including MICL, CLEC‐2, CLEC‐12B,… read more here.
Keywords: physiological roles; roles involvement; type lectin; disease ... See more keywords
Molecular characteristics and physiological roles of Na+–K+–Cl− cotransporter 2
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29997
Abstract: Na+–K+–Cl− cotransporter 2 (NKCC2; SLC12A1) is an integral membrane protein that comes as three splice variants and mediates the cotranslocation of Na+, K+, and Cl− ions through the apical membrane of the thick ascending loop… read more here.
Keywords: physiological roles; physiology; molecular characteristics; characteristics physiological ... See more keywords
The Functional Properties, Physiological Roles, Channelopathy and Pharmacological Characteristics of the Slack (KCNT1) Channel.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-16-4254-8_18
Abstract: The KCNT1 gene encodes the sodium-activated potassium channel that is abundantly expressed in the central nervous system of mammalians and plays an important role in reducing neuronal excitability. Structurally, the KCNT1 channel is absent of… read more here.
Keywords: channel; roles channelopathy; properties physiological; kcnt1 channel ... See more keywords
Moving beyond disease to function: Physiological roles for polyglutamine-rich sequences in cell decisions.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2021.01.003
Abstract: Glutamine-rich tracts, also known as polyQ domains, have received a great deal of attention for their role in multiple neurodegenerative diseases, including Huntington's disease (HD), spinocerebellar ataxia (SCA), and others [22], [27]. Expansions in the… read more here.
Keywords: physiological roles; beyond disease; function physiological; moving beyond ... See more keywords
Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.
Sign Up to like & getrecommendations! Published in 2018 at "Cell systems"
DOI: 10.1016/j.cels.2018.05.016
Abstract: The genetics of individual lipid species and their relevance in disease is largely unresolved. We profiled a subset of storage, signaling, membrane, and mitochondrial liver lipids across 385 mice from 47 strains of the BXD… read more here.
Keywords: physiological roles; systems analyses; roles genetic; analyses reveal ... See more keywords
Physiological roles of tryptophan decarboxylase revealed by overexpression of SlTDC1 in tomato
Sign Up to like & getrecommendations! Published in 2021 at "Scientia Horticulturae"
DOI: 10.1016/j.scienta.2020.109672
Abstract: Abstract SlTDC1, a candidate gene for tryptophan decarboxylase (TDC) in tomato, was the focus of this study because SlTDC1 may play a role in the biosynthesis of serotonin (Hano et al., 2017), which is a… read more here.
Keywords: decarboxylase revealed; tryptophan decarboxylase; roles tryptophan; physiological roles ... See more keywords
SsrA and SmpB have multifaceted physiological roles in the black rot pathogen Xanthomonas campestris pathovar campestris.
Sign Up to like & getrecommendations! Published in 2023 at "FEMS microbiology letters"
DOI: 10.1093/femsle/fnad009
Abstract: SsrA and SmpB are known to play important roles in translational quality control and are essential for virulence in many human and animal pathogenic bacteria. The physiological roles and contribution of SsrA and SmpB to… read more here.
Keywords: ssra smpb; smpb; physiological roles; xanthomonas campestris ... See more keywords
DCAF1 (VprBP): emerging physiological roles for a unique dual-service E3 ubiquitin ligase substrate receptor
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjy085
Abstract: Cullin-RING ligases (CRLs) comprise a large group of modular eukaryotic E3 ubiquitin ligases. Within this family, the CRL4 ligase (consisting of the Cullin4 [CUL4] scaffold protein, the Rbx1 RING finger domain protein, the damaged DNA… read more here.
Keywords: protein; physiological roles; ligase; substrate receptor ... See more keywords
Octopamine and tyramine signalling in Aedes aegypti: Molecular characterization and insight into potential physiological roles
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0281917
Abstract: In insects, the biogenic amines octopamine (OA) and tyramine (TA) are involved in controlling several physiological and behavioural processes. OA and TA act as neurotransmitters, neuromodulators or neurohormones, performing their functions by binding to specific… read more here.
Keywords: aedes aegypti; physiological roles; tyramine signalling; octopamine tyramine ... See more keywords
Hydrogen sulfide: physiological roles and therapeutic implications against COVID-19.
Sign Up to like & getrecommendations! Published in 2023 at "Current medicinal chemistry"
DOI: 10.2174/0929867330666230502111227
Abstract: The COVID-19 pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) poses a major menace to economic and public health worldwide. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) are two host… read more here.
Keywords: sulfide physiological; physiological roles; roles therapeutic; implications covid ... See more keywords