Mutasynthesis of Physostigmines in Myxococcus xanthus.
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DOI: 10.1021/acs.orglett.1c02374
Abstract: The alkaloid physostigmine is an approved anticholinergic drug and an important lead structure for the development of novel therapeutics. Using a complementary approach that merged chemical synthesis with pathway refactoring, we produced a series of… read more here.
Keywords: myxococcus xanthus; physostigmines myxococcus; mutasynthesis physostigmines;