Evidence for a PI3-kinase independent pathway in the regulation of Rap1b activation downstream of the P2Y12 receptor in platelets
Sign Up to like & getrecommendations! Published in 2022 at "Platelets"
DOI: 10.1080/09537104.2022.2071855
Abstract: Abstract Platelet activation by adenosine diphosphate (ADP) is mediated through two G-protein-coupled receptors, P2Y1 and P2Y12, which signal through Gq and Gi, respectively. P2Y1 stimulation leads to phospholipase C activation and an increase in cytosolic… read more here.
Keywords: pi3 kinase; p2y12; activation; rap1b activation ... See more keywords
CCL6 promotes M2 polarization and inhibits macrophage autophagy by activating PI3‐kinase/Akt signalling pathway during skin wound healing
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Dermatology"
DOI: 10.1111/exd.14718
Abstract: The transition of macrophages from the proinflammatory M1 to the anti‐inflammatory M2 phenotype is crucial during the wound healing process. In this study, we assess the role of chemokine (C‐C motif) ligand 6 (CCL6) in… read more here.
Keywords: pi3 kinase; wound healing; macrophage autophagy; ccl6 ... See more keywords
Combined MEK and Pi3′-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15599
Abstract: Anaplastic thyroid cancers and radioiodine resistant thyroid cancer are posing a major treat since surgery combined with Iodine131 therapy is ineffective on them. Small-molecule inhibitors are presenting a new hope for patients, but often lead… read more here.
Keywords: cancer; pi3 kinase; thyroid cancer;
Two Monogenetic Disorders, Activated PI3-Kinase-δ Syndrome 2 and Smith–Magenis Syndrome, in One Patient: Case Report and a Literature Review of Neurodevelopmental Impact in Primary Immunodeficiencies Associated With Disturbed PI3K Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2021.688022
Abstract: Activated PI3-kinase-δ syndrome 2 (APDS2) is caused by autosomal dominant mutations in the PIK3R1 gene encoding the p85α, p55α, and p50α regulatory subunits. Most diagnosed APDS2 patients carry mutations affecting either the splice donor or… read more here.
Keywords: magenis syndrome; kinase syndrome; activated pi3; pi3 kinase ... See more keywords
Disorders Related to PI3Kδ Hyperactivation: Characterizing the Clinical and Immunological Features of Activated PI3-Kinase Delta Syndromes
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2021.702872
Abstract: Phosphoinositide-3-kinase δ (PI3Kδ) is found in immune cells and is part of the PI3K/AKT/mTOR/S6K signalling pathway essential to cell survival, growth and differentiation. Hyperactivation of PI3Kδ enzyme results in Activated PI3-kinase delta syndrome (APDS). This… read more here.
Keywords: kinase delta; disorders related; activated pi3; kinase ... See more keywords
Targeting PTEN Regulation by Post Translational Modifications
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DOI: 10.3390/cancers14225613
Abstract: Simple Summary Cancer cells accumulate genetic alterations that improve their proliferation, survival, and migration capabilities. One of the most frequently altered signaling nodes in human cancer is the PI3-kinase /PTEN pathway. Most therapeutic efforts thus… read more here.
Keywords: translational modifications; pi3 kinase; post translational; kinase ... See more keywords
Management of Gastro-Intestinal Toxicity of the Pi3 Kinase Inhibitor: Optimizing Future Dosing Strategies
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15082279
Abstract: Simple Summary Targeted therapies are becoming more widespread in the treatment of indolent B-cell malignancies, as has been the case for chronic lymphocytic leukemias and small B-cell non-Hodgkin lymphomas. Due to the severity of these… read more here.
Keywords: pi3 kinase; toxicity pi3; inhibitor; kinase ... See more keywords