Imidazobenzodiazepine PI320 Relaxes Mouse Peripheral Airways by Inhibiting Calcium Mobilization.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2022-0084oc
Abstract: Asthma is a common respiratory disease characterized, in part, by excessive airway smooth muscle (ASM) contraction (airway hyperresponsiveness, AHR). Various γ-aminobutyric acid type A receptor (GABAAR) activators, including benzodiazepines, relax ASM. The GABAAR is a… read more here.
Keywords: peripheral airways; mobilization; pi320 relaxes; asm ... See more keywords
Anxiolytics for Bronchodilation: Refinements to GABAA Agonists for Asthma Relief
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2022-0287ed
Abstract: In 1961, Julius Axelrod and colleagues (1) described the effects of psychotropic drugs on the uptake of catecholamine neurotransmitters by several tissues, including at the nerve endings (2), that opened the floodgates of investigation into… read more here.
Keywords: gabaa; pi320; relaxation; gaba ... See more keywords