Buparlisib, a PI3K inhibitor, demonstrates acceptable tolerability and preliminary activity in a phase I trial of patients with advanced leukemias
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24568
Abstract: Phosphatidylinositol‐3‐kinase (PI3K) signaling plays a crucial role in oncogene‐mediated tumor growth and proliferation. Buparlisib (BKM120) is an oral pan‐class I PI3K inhibitor. This phase I study was conducted to determine the dose limiting toxicity (DLT)… read more here.
Keywords: phase; pi3k; buparlisib; day ... See more keywords
PI3Kδ Is a Therapeutic Target in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30307
Abstract: Class I phosphoinositide 3‐kinase (PI3K) signaling is a major pathway in human cancer development and progression. Among the four PI3K isoforms, PI3Kα and PI3Kβ are ubiquitously expressed, whereas PI3Kγ and PI3Kδ are found primarily in… read more here.
Keywords: hepatocellular carcinoma; pi3k; hcc; advanced hcc ... See more keywords
Hydrogen sulfide attenuates uranium‐induced kidney cells pyroptosis via upregulation of PI3K/AKT/mTOR signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23220
Abstract: We have identified that hydrogen sulfide (H2S), a gaseous mediator, plays a crucial role in antioxidative, anti‐inflammatory, and cytoprotective effects on uranium (U)‐triggered rat nephrotoxicity. Pyroptosis is a special mode of inflammation and programmed cell… read more here.
Keywords: pi3k; pi3k akt; pyroptosis; akt mtor ... See more keywords
Phosphoinositide‐3 kinase gamma regulates caspase‐1 activation and leukocyte recruitment in acute murine gout
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.ma1118-470rr
Abstract: This study investigates the participation of PI3Kγ in the development of joint inflammation and dysfunction in an experimental model of acute gout in mice. Acute gout was induced by injection of monosodium urate (MSU) crystals… read more here.
Keywords: caspase activation; gout; msu; pi3k ... See more keywords
Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles
Sign Up to like & getrecommendations! Published in 2017 at "PROTEOMICS"
DOI: 10.1002/pmic.201600371
Abstract: Epidemiological studies suggest that diabetes and obesity increases the risk of colorectal cancer (CRC) and lowers the patient survival rate. An important attribute in diabetes and obesity is the presence of high levels of growth… read more here.
Keywords: pi3k; pi3k akt; evs secreted; signalling pathway ... See more keywords
PI3K/Akt/CncC signaling pathway mediates response to EPN-Bt infection in Holotrichia parallela larvae.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.7337
Abstract: BACKGROUND Combining the entomopathogenic nematode (EPN), Heterorhabditis beicherriana LF strain and Bacillus thuringiensis (Bt) HBF-18 strain is a practical strategy to manage the larvae of Holotrichia parallela Motschulsky (white grubs). However, the mechanisms underlying the… read more here.
Keywords: pi3k; pi3k akt; cncc; epn infection ... See more keywords
Potential anticancer effects of cyclo(-Pro-Tyr) against N-diethyl nitrosamine induced hepatocellular carcinoma in mouse through PI3K/AKT signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental toxicology"
DOI: 10.1002/tox.23395
Abstract: The oceans are considered as magnificent source of bioactive metabolites, of which marine sponges associated organisms are being the most effective producers of various bioactive molecules. We previously reported that cyclo(-Pro-Tyr) (CPT), a dipeptide from… read more here.
Keywords: hepatocellular carcinoma; pi3k; akt signaling; pro tyr ... See more keywords
Uranium induces kidney cells apoptosis via reactive oxygen species generation, endoplasmic reticulum stress and inhibition of PI3K/AKT/mTOR signaling in culture
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23453
Abstract: Uranium (U) induces generation of excessive intracellular reactive oxygen species (ROS), which is generally considered as a possible mediator of U‐triggered kidney tubular cells injury and nephrotoxicity. Our goal is designed to elucidate that the… read more here.
Keywords: pi3k; stress; apoptosis; pi3k akt ... See more keywords
Slit2/Robo1 signaling is involved in angiogenesis of glomerular endothelial cells exposed to a diabetic-like environment
Sign Up to like & getrecommendations! Published in 2017 at "Angiogenesis"
DOI: 10.1007/s10456-017-9592-3
Abstract: Abnormal angiogenesis plays a pathological role in diabetic nephropathy (DN), contributing to glomerular hypertrophy and microalbuminuria. Slit2/Robo1 signaling participates in angiogenesis in some pathological contexts, but whether it is involved in glomerular abnormal angiogenesis of… read more here.
Keywords: pi3k; angiogenesis; robo1 signaling; slit2 robo1 ... See more keywords
MicroRNA miR-212 regulates PDCD4 to attenuate Aβ25–35-induced neurotoxicity via PI3K/AKT signaling pathway in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Letters"
DOI: 10.1007/s10529-020-02915-z
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disease in the elderly. MicroRNA (miRNA) miR-212-3p (miR-212) has been reported to dysregulated in many neurodegenerative diseases including AD. However, the mechanism and function of miR-212 in AD… read more here.
Keywords: pi3k; pdcd4; alzheimer disease; pi3k akt ... See more keywords
PI3K Is a Linker Between L-selectin and PSGL-1 Signaling to IL-18 Transcriptional Activation at the Promoter Level
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation"
DOI: 10.1007/s10753-017-0711-5
Abstract: Abstract L-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) are adhesion molecules which induce similar physiological events. Our previous paper showed that phosphatidylinositol 3-kinase (PI3K) played a crucial role in L-selectin- and PSGL-1-mediated F-actin redistribution and assembly… read more here.
Keywords: pi3k; linker selectin; level; selectin psgl ... See more keywords