PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposit formation
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DOI: 10.1091/mbc.e19-05-0303
Abstract: Excess of Aβ42 peptide is considered a hallmark of the disease. Here we express the human Aβ42 peptide to assay the neuroprotective effects of PI3K in adult Drosophila melanogaster. The neuronal expression of the human… read more here.
Keywords: synapse loss; toxicity; pi3k; pi3k activation ... See more keywords
Abl-mediated PI3K activation regulates macrophage podosome formation
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DOI: 10.1242/jcs.234385
Abstract: ABSTRACT Podosomes play crucial roles in macrophage adhesion and migration. Wiskott–Aldrich syndrome protein (WASP; also known as WAS)-mediated actin polymerization is one of the key events initiating podosome formation. Nevertheless, membrane signals to trigger WASP… read more here.
Keywords: pi3k activation; src hck; activation; podosome formation ... See more keywords