Mutations in TOP2B cause autosomal‐dominant hereditary hearing loss via inhibition of the PI3K‐Akt signalling pathway
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DOI: 10.1002/1873-3468.13482
Abstract: Hereditary hearing impairment is a clinically and genetically heterogeneous disease. Whole‐exome sequencing was performed on seven affected and six unaffected members in a large Chinese family with autosomal‐dominant nonsyndromic hearing loss. The pathogenic variant of… read more here.
Keywords: hearing loss; autosomal dominant; pi3k akt;
Targeting PI3Kγ/AKT Pathway Remodels LC3‐Associated Phagocytosis Induced Immunosuppression After Radiofrequency Ablation
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DOI: 10.1002/advs.202102182
Abstract: Residual tumors after insufficient radiofrequency ablation (IRFA) shows accelerated progression and anti‐PD‐1 resistance. It is also reported that macrophages infiltrating into residual tumors leads to anti‐PD‐1 resistance. Elements of autophagy have been detected to conjugate… read more here.
Keywords: akt pathway; lc3 associated; residual tumors; pi3k akt ... See more keywords
Apoptin‐derived peptide reverses cisplatin resistance in gastric cancer through the PI3K–AKT signaling pathway
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DOI: 10.1002/cam4.1380
Abstract: The prognosis of gastric cancer (GC) remains poor due to clinical drug resistance, and novel drugs are urgently needed. Apoptin‐derived peptide (AdP) is an antitumor polypeptide constructed in our laboratory that has been used to… read more here.
Keywords: cancer; signaling pathway; resistance; pi3k akt ... See more keywords
LncRNA‐LOC101928316 contributes to gastric cancer progression through regulating PI3K‐Akt‐mTOR signaling pathway
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DOI: 10.1002/cam4.2165
Abstract: Long noncoding RNA (lncRNA) has played the important function in regulation of various biological processes and in diagnostic value has been widely appreciated. In the present study, we have found that LOC101928316 was significantly downregulated… read more here.
Keywords: gastric cancer; mtor signaling; pi3k akt; signaling pathway ... See more keywords
Selenoprotein M stimulates the proliferative and metastatic capacities of renal cell carcinoma through activating the PI3K/AKT/mTOR pathway
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DOI: 10.1002/cam4.2403
Abstract: High‐throughput sequencing methods have facilitated the identification of novel selenoproteins, which exert a vital role in the development and progression of tumor diseases. Recently, Selenoprotein M (SELM) is upregulated in several types of cancer. However,… read more here.
Keywords: renal cell; selm; rcc; cell carcinoma ... See more keywords
Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway
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DOI: 10.1002/cam4.2723
Abstract: Hepatocellular carcinoma (HCC) is a devastating and highly metastatic cancer worldwide. Metformin (MET) is the priority drug for treatment of type 2 diabetes; however, it possesses multiple biological effects like anticancer and hepatoprotective activity. Herein,… read more here.
Keywords: apoptosis; pi3k akt; apoptosis autophagy; aloin met ... See more keywords
Characterization, management, and risk factors of hyperglycemia during PI3K or AKT inhibitor treatment
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DOI: 10.1002/cam4.4579
Abstract: The phosphoinositide 3‐kinase (PI3K)/protein kinase B (AKT) pathway controls insulin sensitivity and glucose metabolism. Hyperglycemia is one of the most common on‐target adverse effects (AEs) of PI3K/AKT inhibitors. As several PI3K and AKT inhibitors are… read more here.
Keywords: pi3k akt; factors hyperglycemia; management; risk factors ... See more keywords
PTEN promotes intervertebral disc degeneration by regulating nucleus pulposus cell behaviors
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DOI: 10.1002/cbin.11258
Abstract: Intervertebral disc degeneration (IDD) is induced by multiple factors including increased apoptosis, decreased survival, and reduced extracellular matrix (ECM) synthesis in the nucleus pulposus (NP) cells. The tumor suppressor phosphatase and tensin homolog deleted from… read more here.
Keywords: disc; pi3k akt; intervertebral disc; nucleus pulposus ... See more keywords
Hypoxia‐induced SPOP attenuates the mobility of trophoblast cells through inhibition of the PI3K/AKT/GSK3β pathway
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DOI: 10.1002/cbin.11501
Abstract: Placental hypoxia has been implicated in pregnancy pathologies such as pre‐eclampsia and intrauterine growth restriction. However, the underlying mechanism by which the trophoblasts respond to hypoxia remains unclear. Speckle‑type POZ protein (SPOP), an E3 ubiquitin… read more here.
Keywords: pi3k akt; hypoxia; gsk3 pathway; cocl2 ... See more keywords
RING finger protein 128 (RNF128) regulates malignant biological behaviors of colorectal cancer cells via PI3K/AKT signaling pathway
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DOI: 10.1002/cbin.11835
Abstract: This study was designed and conducted to clarify the impact of RNF128 expression on malignant biological behaviors of colorectal cancer (CRC) cells and the underlying mechanism. The expression of RNF128 in CRC tissues was analyzed… read more here.
Keywords: pi3k akt; rnf128; expression; crc ... See more keywords
Effects of GABAB receptor positive allosteric modulator BHF177 and IRS‐1 on apoptosis of hippocampal neurons in rats with refractory epilepsy via the PI3K/Akt pathway
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DOI: 10.1002/cbin.11839
Abstract: The present study was conducted to determine the effects of the γ‐aminobutyric acid B (GABAB) receptor positive allosteric modulator BHF177 on refractory epilepsy (RE). An RE rat model was initially established via treatment with lithium‐pilocarpine.… read more here.
Keywords: pi3k akt; apoptosis; gabab receptor; hippocampal neurons ... See more keywords