Antidepressant-like effect of valproic acid—Possible involvement of PI3K/Akt/mTOR pathway
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.04.015
Abstract: Rationale: Few studies suggest that antidepressants exert their effects by activating some signaling pathways, including the phosphatidylinositol 3‐kinase (PI3K). Moreover, valproic acid (VPA) activates the PI3K pathway. Thus, here we investigated the antidepressant‐like effect of… read more here.
Keywords: pi3k ggr; like effect; effect; mtor ... See more keywords
Downregulation of PI3K‐&ggr; in a mouse model of sepsis‐induced myocardial dysfunction
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DOI: 10.1016/j.cyto.2017.04.018
Abstract: HighlightsMechanism for SIMD.Relies on PI3K/AKT pathway.PI3K might be a therapeutic target. Abstract A key component during sepsis is the phosphoinositide 3‐kinase (PI3K)/protein kinase B (Akt) signaling pathway, of which the PI3K‐&ggr; isoform is a major… read more here.
Keywords: pi3k ggr; pi3k; induced myocardial; sepsis induced ... See more keywords
Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth
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DOI: 10.1161/circulationaha.117.030352
Abstract: Background: Anthracyclines, such as doxorubicin (DOX), are potent anticancer agents for the treatment of solid tumors and hematologic malignancies. However, their clinical use is hampered by cardiotoxicity. This study sought to investigate the role of… read more here.
Keywords: pi3k ggr; kinase; inhibition; cardiotoxicity ... See more keywords