Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases.
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DOI: 10.1021/acs.jmedchem.9b00390
Abstract: Polypharmacology is a promising paradigm in modern drug discovery. Herein, we have discovered a series of novel PI3K and HDAC dual inhibitors in which the hydroxamic acid moiety as the zinc binding functional group was… read more here.
Keywords: quinazoline; design synthesis; biological evaluation; simultaneously targeting ... See more keywords