Abstract A25: Activating alterations of p110 subunits determine PI3K isoform selectivity in prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.pi3k-mtor18-a25
Abstract: Oncogenic activity of PI3K mutated tumors is often dependent on different PI3K isoforms. In breast cancer PI3Kα activating mutations are dominant drivers, whereas in PTEN-deficient prostate cancer such activity is thought to be driven by… read more here.
Keywords: pi3k isoform; prostate cancer; pi3k; cancer ... See more keywords
The Pro-Fibrotic Response to Lens Injury Is Signaled in a PI3K Isoform-Specific Manner
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DOI: 10.3390/biom12091181
Abstract: The signaling inputs that function to integrate biochemical and mechanical cues from the extracellular environment to alter the wound-repair outcome to a fibrotic response remain poorly understood. Here, using a clinically relevant post-cataract surgery wound… read more here.
Keywords: pi3k isoform; fibrotic response; role; isoform specific ... See more keywords