Attenuating PI3K isoforms in pancreatic cancer: Focus on immune PI3Kγ.
Sign Up to like & getrecommendations! Published in 2017 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2017.04.013
Abstract: Phosphoinositide 3-kinases PI3Ks are major drug targets in oncology. Their role is far from being completely understood in pancreatic ductal adenocarcinoma. Pancreatic cancer is a dismal disease with limited therapeutic options except for surgery. We… read more here.
Keywords: pi3k; attenuating pi3k; isoforms pancreatic; pancreatic cancer ... See more keywords
PIK3CB/p110&bgr; is a selective survival factor for glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Neuro-Oncology"
DOI: 10.1093/neuonc/nox181
Abstract: Background Glioblastoma (GBM) is difficult to treat. Phosphoinositide 3-kinase (PI3K) is an attractive therapeutic target for GBM; however, targeting this pathway to effectively treat GBM is not successful because the roles of PI3K isoforms remain… read more here.
Keywords: pi3k isoforms; gbm; p110; pik3cb p110 ... See more keywords
Phosphoinositol 3-kinase-driven NET formation involves different isoforms and signaling partners depending on the stimulus
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1042686
Abstract: Neutrophil extracellular traps (NETs) serve to immobilize and kill pathogens, but also can contribute to the progression of several inflammatory and auto-immune diseases, as well as cancer. Whence the importance of elucidating the mechanisms underlying… read more here.
Keywords: pi3k; signaling partners; pi3k isoforms; net formation ... See more keywords