A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases
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DOI: 10.1126/scitranslmed.abl6328
Abstract: Cyclic adenosine 3′,5′-monophosphate (cAMP)–elevating agents, such as β2-adrenergic receptor (β2-AR) agonists and phosphodiesterase (PDE) inhibitors, remain a mainstay in the treatment of obstructive respiratory diseases, conditions characterized by airway constriction, inflammation, and mucus hypersecretion. However,… read more here.
Keywords: camp; inflammation; pi3k mimetic; mimetic peptide ... See more keywords