Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23182
Abstract: Dihydromethysticin (DHM), a natural compound derived from Kava, has been reported to be effective against mental disorders and some malignant tumors. However, little is known about the inhibitory effect of DHM on colorectal cancer (CRC).… read more here.
Keywords: nlrc3 pi3k; via nlrc3; cancer; dhm ... See more keywords
Osteopontin Regulates Endometrial Stromal Cell Migration in Endometriosis through the PI3K Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Sciences"
DOI: 10.1007/s43032-020-00301-8
Abstract: Endometriosis is generally characterized as a tumor-like disease because of its potential for distant metastasis and local tissue invasion, while whether osteopontin (OPN) plays a role in the pathogenesis of endometriosis has not been thoroughly… read more here.
Keywords: endometriosis; pi3k; migration; expression ... See more keywords
Anti-tumor activity of dual inhibition of phosphatidylinositol 3-kinase and MDM2 against clear cell ovarian carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2019.08.028
Abstract: INTRODUCTION PI3K pathway signaling has received attention as a molecular target in clear cell ovarian carcinoma (CCOC). MDM2 is one of the AKT effectors in the PI3K pathway, which binds to and degrades p53. In… read more here.
Keywords: mdm2; dual inhibition; expression; cell ... See more keywords
(-)-4-O-(4-O-β-D-glucopyranosylcaffeoyl) quinic acid enhanced the efficacy of anti-PD-L1 against esophageal carcinoma through inhibiting PI3K pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Immunopharmacology and immunotoxicology"
DOI: 10.1080/08923973.2021.1990315
Abstract: PURPOSE Using antibodies to block the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway as an immunotherapy has achieved great success in the clinical treatment of various types of carcinoma. However, the efficacy… read more here.
Keywords: glucopyranosylcaffeoyl quinic; inhibiting pi3k; quinic acid; efficacy anti ... See more keywords
A randomized adaptive phase II/III study of buparlisib, a pan-class I PI3K inhibitor, combined with paclitaxel for the treatment of HER2– advanced breast cancer (BELLE-4)
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Oncology"
DOI: 10.1093/annonc/mdw562
Abstract: Background Phosphatidylinositol 3-kinase (PI3K) pathway activation in preclinical models of breast cancer is associated with tumor growth and resistance to anticancer therapies, including paclitaxel. Effects of the pan-Class I PI3K inhibitor buparlisib (BKM120) appear synergistic… read more here.
Keywords: phase; pi3k; pfs; study ... See more keywords
PO-448 The AP-1 trancriptional complex regulates AXL-induced resistance to PI3K pathway inhibition in head and neck and esophageal cancer
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.959
Abstract: Introduction Phosphoinositide-3-kinase (PI3K) pathway is often hyper activated in Head and Neck and Esopgageal squamous cell carcinoma leading to tumour cell proliferation and survival. Inhibition of the PI3K pathway using the isoform specific inhibitor BYL719,… read more here.
Keywords: byl719; axl; inhibition; resistance ... See more keywords
Abstract B09: Structural biology of the PI3K pathway: On with phosphorylation, down with ubiquitination
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.pi3k-mtor18-b09
Abstract: The regulation of the PI3K pathway is central to cell growth and is deregulated in diseases such as cancer and cardiovascular disease. We are using biochemistry, structural biology, and chemical biology to probe the activation… read more here.
Keywords: biology pi3k; biology; structural biology; phosphorylation ... See more keywords
Abstract B31: Single-cell multiplex immunofluorescence of formalin-fixed, paraffin-embedded prostate cancer tissue identifies PI3K pathway activation in two prospective cohort studies
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.pi3k-mtor18-b31
Abstract: Background: The PI3K pathway is activated in a large proportion of solid cancers, including prostate cancer. Loss of its inhibitor PTEN is associated with higher risk of lethal prostate cancer. However, clinical trials of PI3K… read more here.
Keywords: activation; cancer; pi3k pathway; prostate cancer ... See more keywords
Management of Phosphatidylinositol-3-Kinase Inhibitor-Associated Hyperglycemia
Sign Up to like & getrecommendations! Published in 2022 at "Integrative Cancer Therapies"
DOI: 10.1177/15347354211073163
Abstract: Phosphatidylinositol-3-kinase (PI3K) pathway hyperactivation has been associated with the development of cancer and treatment resistance. PI3K inhibitors are now used to treat hormone receptor-positive (HR+), human epidermal growth factor receptor-2–negative (HER2−), PIK3CA-mutated advanced breast cancer.… read more here.
Keywords: hyperglycemia; pi3k pathway; phosphatidylinositol kinase; associated hyperglycemia ... See more keywords
Association of phosphatidylinositol 3-kinase (PI3K) pathway activation with increased immune checkpoint expression in colorectal cancer (CRC) patients.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.4_suppl.653
Abstract: 653Background: PI3K pathway is a known modulator of anti-tumor immune response and is frequently activated in CRC through genetic alterations such as PTEN loss (PTENloss) and PIK3CA mutations (PIK3... read more here.
Keywords: pathway activation; kinase pi3k; association phosphatidylinositol; activation increased ... See more keywords
PI3K pathway mutations are associated with longer time to local progression after radioembolization of colorectal liver metastases
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15278
Abstract: Purpose To establish the relationship between common mutations in the MAPK and PI3K signaling pathways and local progression after radioembolization. Materials and Methods Retrospective review of a HIPAA-compliant institutional review-board approved database identified 40 patients… read more here.
Keywords: progression radioembolization; local progression; time; progression ... See more keywords