Insulin-Driven PI3K-AKT Signaling in the Hepatocyte Is Mediated by Redundant PI3Kα and PI3Kβ Activities and Is Promoted by RAS.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.03.010
Abstract: Phosphatidylinositol-3-kinase (PI3K) activity is aberrant in tumors, and PI3K inhibitors are investigated as cancer therapeutics. PI3K signaling mediates insulin action in metabolism, but the role of PI3K isoforms in insulin signaling remains unresolved. Defining the… read more here.
Keywords: insulin; pi3k; pi3k pi3k; insulin driven ... See more keywords
Biophysical and structural characterization of novel RAS-binding domains (RBDs) of PI3Kα and PI3Kγ.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.166838
Abstract: Phosphatidylinositol-3-kinases (PI3Ks) are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate to generate a key lipid second messenger, phosphatidylinositol 3,4,5-bisphosphate. PI3Kα and PI3Kγ require activation by RAS proteins to stimulate signaling pathways that control cellular growth, differentiation,… read more here.
Keywords: pi3k; ras binding; binding domains; pi3k pi3k ... See more keywords
Abstract 663: The dual PI3K-δ/PI3K-γ inhibitor duvelisib inhibits signaling and proliferation of solid tumor cells expressing PI3K-δ and/or PI3K-γ
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-663
Abstract: Duvelisib is an oral, dual PI3K-δ,γ inhibitor that is FDA-approved for treatment of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) and follicular lymphoma (FL) following ≥2 prior systemic therapies. In addition to targeting malignant B… read more here.
Keywords: pi3k; cell lines; pi3k pi3k; cell ... See more keywords
Strategies to Overcome Failures in T-Cell Immunotherapies by Targeting PI3K-δ and –γ
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.718621
Abstract: PI3K-δ and PI3K-γ are critical regulators of T-cell differentiation, senescence, and metabolism. PI3K-δ and PI3K-γ signaling can contribute to T-cell inhibition via intrinsic mechanisms and regulation of suppressor cell populations, including regulatory T-cells and myeloid… read more here.
Keywords: pi3k; failures cell; pi3k pi3k; overcome failures ... See more keywords