The Role of RP105 in Cardiovascular Disease through Regulating TLR4 and PI3K Signaling Pathways
Sign Up to like & getrecommendations! Published in 2019 at "Current Medical Science"
DOI: 10.1007/s11596-019-2017-3
Abstract: SummaryRaidoprotective 105 (RP105) was first discovered on the surface of mouse B cells and it has been demonstrated that RP105 can function as an inflammatory regulator in cardiovascular disease (CVD), such as myocardial ischemic reperfusion… read more here.
Keywords: signaling pathways; regulating tlr4; pi3k signaling; cardiovascular disease ... See more keywords
Spinal cord injury causes insulin resistance associated with PI3K signaling pathway in hypothalamus
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2020.104839
Abstract: Spinal cord injury (SCI) is an independent risk factor for type 2 diabetes, and may induce insulin resistance that leads to this disease. Studies have shown that greater phosphoinositide 3-kinase (PI3K) activation in the hypothalamus… read more here.
Keywords: signaling pathway; sci; pi3k signaling; insulin resistance ... See more keywords
Treating non-small cell lung cancer by targeting the PI3K signaling pathway
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DOI: 10.1097/cm9.0000000000002195
Abstract: Abstract The phosphosphatidylinositol-3-kinase (PI3K) signaling pathway is one of the most important intracellular signal transduction pathways affecting cell functions, such as apoptosis, translation, metabolism, and angiogenesis. Lung cancer is a malignant tumor with the highest… read more here.
Keywords: lung cancer; cell; signaling pathway; lung ... See more keywords
PIK-24 Inhibits RSV-Induced Syncytium Formation via Direct Interaction with the p85α Subunit of PI3K
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DOI: 10.1128/jvi.01453-22
Abstract: PI3K protein has many functions and regulates various cellular processes. As an important regulatory subunit of PI3K, p85α can regulate the activity of PI3K signaling. ABSTRACT Phosphoinositide-3 kinase (PI3K) signaling regulates many cellular processes, including… read more here.
Keywords: pi3k; pi3k signaling; syncytium formation; p85 ... See more keywords
Abstract 4945: Inhibition of wild-type PI3Kα signaling is required for durable efficacy in PI3Kα mutant cancer cells due to robust re-activation of wild-type PI3Kα signaling
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4945
Abstract: PI3Kα is the most mutated oncogene with a high mutation rate in breast, lung, colorectal, gastric, bladder, and other tumor types. However, current inhibitors have had little efficacy in the clinic due to their inability… read more here.
Keywords: pi3k; pi3k mutant; pi3k signaling; cancer ... See more keywords
Abstract B015: Wildtype RAS activity and PI3K signaling as new vulnerabilities in cells with acquired resistance to sotorasib
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-b015
Abstract: Purpose: Sotorasib (AMG510) has demonstrated remarkable response in lung cancer patients with tumors driven by oncogenic KRASG12C mutation. However, recently published clinical data identified acquired mutations in RAS and other genomic alterations as potential mechanisms… read more here.
Keywords: ras activity; lu65 amgr; resistance; pi3k signaling ... See more keywords
Abstract PR04: Small molecule-mediated activation of Ras elicits inhibition of MAPK and PI3K signaling though pathway feedback
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.pmccavuln16-pr04
Abstract: Oncogenic mutation or hyper-activation of Ras results in aberrant cellular signaling and is responsible for approximately 30% of all human tumors. Therefore, Ras is an outstanding candidate for therapeutic inhibition. However, the discovery of potent… read more here.
Keywords: pi3k; mapk pi3k; inhibition; activation ras ... See more keywords
Control of T lymphocyte fate decisions by PI3K signaling
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DOI: 10.12688/f1000research.26928.1
Abstract: Virtually all aspects of T and B lymphocyte development, homeostasis, activation, and effector function are impacted by the interaction of their clonally distributed antigen receptors with antigens encountered in their respective environments. Antigen receptors mediate… read more here.
Keywords: signaling pathways; control lymphocyte; fate decisions; decisions pi3k ... See more keywords
TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling
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DOI: 10.1371/journal.ppat.1008543
Abstract: Triggering receptor expressed on myeloid cells 2 (TREM2) serves as an anti-inflammatory receptor, negatively regulating the innate immune response. TREM2 is mainly expressed on dendritic cells and macrophages, the target cells of porcine reproductive and… read more here.
Keywords: trem2; response; infection; prrsv infection ... See more keywords
Insulin resistance, autophagy and apoptosis in patients with polycystic ovary syndrome: Association with PI3K signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1091147
Abstract: Polycystic ovary syndrome (PCOS) is a disease in which endocrine metabolic abnormalities coexist with reproductive system abnormalities, with the main clinical manifestations including abnormal menstruation, hirsutism, acne, infertility, and obesity, and it is also a… read more here.
Keywords: autophagy apoptosis; signaling pathway; polycystic ovary; ovary syndrome ... See more keywords
Roxadustat (FG-4592) abated lipopolysaccharides-induced depressive-like symptoms via PI3K signaling
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1048985
Abstract: Background Despite its role in inflammation and the redox system under hypoxia, the effects and molecular mechanisms of hypoxia-inducible factor (HIF) in neuroinflammation-associated depression are poorly explored. Furthermore, Prolyl hydroxylase domain-containing proteins (PHDs) regulate HIF-1;… read more here.
Keywords: induced depressive; via pi3k; depression; pi3k signaling ... See more keywords