The intracellular Ca2+ channel TRPML3 is a PI3P effector that regulates autophagosome biogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2200085119
Abstract: Significance Autophagy involves multiple fusion events, from autophagosome formation to autophagosome-lysosome fusion in a Ca2+-dependent manner. Fundamental unanswered issue- in the autophagy field is how Ca2+ is provided for autophagic membrane fusion. Here, we report… read more here.
Keywords: pi3p; trpml3; effector; channel ... See more keywords
PI3P regulates multiple stages of membrane fusion
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-10-0486
Abstract: The conserved catalysts of intracellular membrane fusion are Rab-family GTPases, effector complexes that bind Rabs for membrane tethering, SNARE proteins of the R, Qa, Qb, and Qc families, and SNARE chaperones of the SM, Sec17/SNAP,… read more here.
Keywords: fusion; membrane fusion; snare; multiple stages ... See more keywords
Exploring the Role of PI3P in Platelets: Insights from a Novel External PI3P Pool
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13040583
Abstract: Phosphoinositides (PIs) play a crucial role in regulating intracellular signaling, actin cytoskeleton rearrangements, and membrane trafficking by binding to specific domains of effector proteins. They are primarily found in the membrane leaflets facing the cytosol.… read more here.
Keywords: role; pi3p; pool pi3p; pi3p binding ... See more keywords