Malarial PI4K inhibitor induced diaphragmatic hernias in rat: Potential link with mammalian kinase inhibition
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DOI: 10.1002/bdr2.2012
Abstract: MMV390048 is an aminopyridine plasmodial PI4K inhibitor, selected as a Plasmodium bloodâstage schizonticide for a next generation of malaria treatments to overcome resistance to current therapies. MMV390048 showed an acceptable preclinical safety profile and progressed… read more here.
Keywords: malarial pi4k; pi4k inhibitor; diaphragmatic hernias;