PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade8641
Abstract: Phosphatidylinositol (PI)regulating enzymes are frequently altered in cancer and have become a focus for drug development. Here, we explore the phosphatidylinositol-5-phosphate 4-kinases (PI5P4K), a family of lipid kinases that regulate pools of intracellular PI, and… read more here.
Keywords: prostate cancer; androgen receptor; supports prostate; cancer ... See more keywords
Abstract A078: Towards understanding noncanonical phosphatidylinositol kinases in the maintenance of prostate metabolism
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2017-a078
Abstract: An estimated 1 in 7 men will develop prostate cancer (PCa) with many progressing to advanced castrate-resistant disease. Unlike other tissue types, normal prostate cell growth and development is heavily dependent on the androgen receptor… read more here.
Keywords: prostate; phosphatidylinositol; metabolism; pi5p4k ... See more keywords