Enhanced diagnostic and prognostic assessment of cardiac amyloidosis using combined 11C-PiB PET/CT and 99mTc-DPD scintigraphy
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-025-07157-7
Abstract: Cardiac amyloidosis (CA) is a severe condition characterized by amyloid fibril deposition in the myocardium, leading to restrictive cardiomyopathy and heart failure. Differentiating between amyloidosis subtypes is crucial due to distinct treatment strategies. The individual… read more here.
Keywords: dpd scintigraphy; amyloidosis; 99mtc dpd; pet 99mtc ... See more keywords
Significance of 11C-PIB PET/CT in cardiac amyloidosis compared with 99mTc-aprotinin scintigraphy: A pilot study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Nuclear Cardiology"
DOI: 10.1007/s12350-018-1260-5
Abstract: AbstractBackgroundThis study was to investigate the significance of 11C-Pittsburgh B (PIB) PET/CT in patients with suspected cardiac amyloidosis compared with 99mTc-aprotinin scintigraphy. MethodsThirteen consecutive patients with suspected cardiac amyloidosis were considered for enrolment in this… read more here.
Keywords: 99mtc aprotinin; study; 11c pib; amyloidosis ... See more keywords
Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analyses of an observational study
Sign Up to like & getrecommendations! Published in 2022 at "The Lancet Neurology"
DOI: 10.1016/s1474-4422(21)00375-6
Abstract: BACKGROUND Insights gained from studying individuals with autosomal dominant Alzheimer's disease have broadly influenced mechanistic hypotheses, biomarker development, and clinical trials in both sporadic and dominantly inherited Alzheimer's disease. Although pathogenic variants causing autosomal dominant… read more here.
Keywords: pib pet; alzheimer disease; disease; dominant alzheimer ... See more keywords
Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons: the Mayo Clinic Study of Aging
Sign Up to like & getrecommendations! Published in 2017 at "International Psychogeriatrics"
DOI: 10.1017/s1041610217002368
Abstract: ABSTRACT Background: Little is known about the association of cortical Aβ with depression and anxiety among cognitively normal (CN) elderly persons. Methods: We conducted a cross-sectional study derived from the population-based Mayo Clinic Study of… read more here.
Keywords: among cognitively; pib; anxiety; study ... See more keywords
Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/s41380-018-0246-7
Abstract: Deposition of amyloid plaques in the brain is one of the two main pathological hallmarks of Alzheimer’s disease (AD). Amyloid positron emission tomography (PET) is a neuroimaging tool that selectively detects in vivo amyloid deposition… read more here.
Keywords: genome wide; deposition; pib pet; amyloid deposition ... See more keywords
A 5-year longitudinal evaluation in patients with mild cognitive impairment by 11C-PIB PET/CT: a visual analysis
Sign Up to like & getrecommendations! Published in 2019 at "Nuclear Medicine Communications"
DOI: 10.1097/mnm.0000000000001004
Abstract: Objective The aim of this study was to evaluate the cerebral amyloid distribution in patients with mild cognitive impairment (MCI), assessed by carbon-11-Pittsburgh compound B (11C-PIB) PET/CT, after 5 years of follow-up. Patients and methods… read more here.
Keywords: 11c pib; pib pet; pib retention; pib ... See more keywords
Visual assessments of 11C-Pittsburgh compound-B PET vs. 18F-flutemetamol PET across the age spectrum
Sign Up to like & getrecommendations! Published in 2024 at "Nuclear Medicine Communications"
DOI: 10.1097/mnm.0000000000001902
Abstract: Objective Visual assessments of amyloid-β PET, used for Alzheimer’s disease (AD) diagnosis and treatment evaluation, require a careful approach when different PET ligands are utilized. Because the gray matter (GM) and white matter (WM) ligand… read more here.
Keywords: pet 18f; flutemetamol pet; 18f flutemetamol; pib pet ... See more keywords
Association Between β-Amyloid Accumulation and Incident Dementia in Individuals 80 Years or Older Without Dementia.
Sign Up to like & getrecommendations! Published in 2024 at "Neurology"
DOI: 10.1212/wnl.0000000000207920
Abstract: BACKGROUND AND OBJECTIVES While the highest prevalence of dementia occurs in individuals older than 80 years, most imaging studies focused on younger populations. The rates of β-amyloid (Aβ) accumulation and the effect of Alzheimer disease… read more here.
Keywords: dementia; accumulation; deposition; pib pet ... See more keywords
Impaired memory is more closely associated with brain beta-amyloid than leukoaraiosis in hypertensive patients with cognitive symptoms
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0191345
Abstract: Background Hypertension is the strongest modifiable risk factor for subcortical ischemic changes and is also a risk factor for Alzheimer’s dementia. We used neuroimaging to investigate the pathological basis of early cognitive symptoms in patients… read more here.
Keywords: memory; beta amyloid; pib pet; cognitive symptoms ... See more keywords
Can 11C-PiB-PET Relative Delivery R1 or 11C-PiB-PET Perfusion Replace 18F-FDG-PET in the Assessment of Brain Neurodegeneration?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Alzheimer's Disease"
DOI: 10.3233/jad-180274
Abstract: Background: Pittsburgh Compound B (PiB) positron emission tomography (PET) is used to visualize in vivo amyloid plaques in the brain. Frequently the PiB examinations are complemented with a fluorodeoxyglucose (FDG) PET scan to further assess… read more here.
Keywords: pib; fdg pet; 11c pib; neurodegeneration ... See more keywords
Statistical Parametric Mapping in Amyloid Positron Emission Tomography
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.849932
Abstract: Alzheimer’s disease (AD), the most common cause of dementia, has limited treatment options. Emerging disease modifying therapies are targeted at clearing amyloid-β (Aβ) aggregates and slowing the rate of amyloid deposition. However, amyloid burden is… read more here.
Keywords: csf; spm; database; csf levels ... See more keywords