Evaluating the Biological Role of Lassa Viral Z Protein-Mediated RIG-I Inhibition Using a Replication-Competent Trisegmented Pichinde Virus System in an Inducible RIG-IN Expression Cell Line
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DOI: 10.1128/jvi.00754-22
Abstract: Lassa virus (LASV) can cause lethal hemorrhagic fever disease in humans but other arenaviruses, such as Pichinde virus (PICV), do not cause obvious disease. We have previously shown that the Z protein of LASV but… read more here.
Keywords: cell; lasv; picv; pichinde virus ... See more keywords
Development of a Recombinant Pichinde Virus-Vectored Vaccine against Turkey Arthritis Reovirus and Its Immunological Response Characterization in Vaccinated Animals
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DOI: 10.3390/pathogens10020197
Abstract: Vaccination may be an effective way to reduce turkey arthritis reovirus (TARV)-induced lameness in turkey flocks. However, there are currently no commercial vaccines available against TARV infection. Here, we describe the use of reverse genetics… read more here.
Keywords: turkey; recombinant pichinde; arthritis reovirus; pichinde virus ... See more keywords
Efficacy and Immunogenicity of Recombinant Pichinde Virus-Vectored Turkey Arthritis Reovirus Subunit Vaccine
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DOI: 10.3390/vaccines10040486
Abstract: We created a recombinant live pichinde virus-vectored bivalent codon optimized subunit vaccine that expresses immunogenic Sigma C and Sigma B proteins of turkey arthritis reovirus. The vaccine virus could be transmitted horizontally immunizing the non-vaccinated… read more here.
Keywords: subunit vaccine; virus vectored; turkey arthritis; pichinde virus ... See more keywords