Sequence-Dependent Conformational Properties of PGGG Motif in Tau Repeats: Insights from Molecular Dynamics Simulations of Narrow Pick Filament.
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DOI: 10.1021/acschemneuro.2c00602
Abstract: Tauopathies are a class of neurodegenerative diseases correlated with the presence of pathological Tau fibrils as a diagnostic marker. The microtubule-binding repeat region of Tau protein, which includes R1, R2, R3, and R4 repeats, constitutes… read more here.
Keywords: narrow pick; tau; molecular dynamics; sequence ... See more keywords