Unconventional PDZ Recognition Revealed in α7 nAChR-PICK1 Complexes
Sign Up to like & getrecommendations! Published in 2024 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.4c00138
Abstract: PDZ domains are modular domains that conventionally bind to C terminal or internal motifs of target proteins to control cellular functions through the regulation of protein complex assemblies. Almost all reported structures of PDZ-target protein… read more here.
Keywords: pdz; unconventional pdz; pdz recognition; protein ... See more keywords
PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1716506115
Abstract: Significance Parkinson’s disease (PD) is the second most common neurodegenerative disorder. It is characterized by progressive deterioration of motor function caused by loss of dopamine-producing neurons. Currently, there is no treatment that could stop the… read more here.
Keywords: ligase activity; parkin; ubiquitin ligase; pick1 ... See more keywords
PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvad057
Abstract: Abstract Context Metabolic disorders such as obesity represent a major health challenge. Obesity alone has reached epidemic proportions, with at least 2.8 million people worldwide dying annually from diseases caused by overweight or obesity. The… read more here.
Keywords: pick1; pick1 deficient; glucose tolerance; deficient mice ... See more keywords