Synthesis of (-)-Picrotoxinin by Late-Stage Strong Bond Activation.
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DOI: 10.1021/jacs.0c05042
Abstract: We report a concise, stereocontrolled synthesis of the neurotoxic sesquiterpenoid (-)-picrotoxinin (1, PXN). The brevity of the route is due to regio- and stereoselective formation of the [4.3.0] bicyclic core by incorporation of a symmetrizing… read more here.
Keywords: picrotoxinin late; bond; strong bond; synthesis picrotoxinin ... See more keywords