Stepwise phosphorylation and SUMOylation of PIDD1 drive PIDDosome assembly in response to DNA repair failure
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DOI: 10.1038/s41467-024-53412-0
Abstract: SUMOylation regulates numerous cellular stress responses, yet targets in the apoptotic machinery remain elusive. We show that a single, DNA damage-induced monoSUMOylation event controls PIDDosome (PIDD1/RAIDD/caspase-2) formation and apoptotic death in response to unresolved DNA… read more here.
Keywords: piddosome; sumoylation; piddosome assembly; pidd1 ... See more keywords