Piezo channels and GsMTx4: Two milestones in our understanding of excitatory mechanosensitive channels and their role in pathology.
Sign Up to like & getrecommendations! Published in 2017 at "Progress in biophysics and molecular biology"
DOI: 10.1016/j.pbiomolbio.2017.07.011
Abstract: Discovery of Piezo channels and the reporting of their sensitivity to the inhibitor GsMTx4 were important milestones in the study of non-selective cationic mechanosensitive channels (MSCs) in normal physiology and pathogenesis. GsMTx4 had been used… read more here.
Keywords: piezo channels; muscle; piezo; pathology ... See more keywords
A protein interaction mechanism for suppressing the mechanosensitive Piezo channels
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01712-z
Abstract: Piezo proteins are bona fide mammalian mechanotransduction channels for various cell types including endothelial cells. The mouse Piezo1 of 2547 residues forms a three-bladed, propeller-like homo-trimer comprising a central pore-module and three propeller-structures that might… read more here.
Keywords: piezo channels; mechanosensitive piezo; piezo; mechanotransduction ... See more keywords
Voltage gating of mechanosensitive PIEZO channels
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DOI: 10.1038/s41467-018-03502-7
Abstract: Mechanosensitive PIEZO ion channels are evolutionarily conserved proteins whose presence is critical for normal physiology in multicellular organisms. Here we show that, in addition to mechanical stimuli, PIEZO channels are also powerfully modulated by voltage… read more here.
Keywords: voltage; piezo channels; mechanosensitive piezo; piezo ... See more keywords
A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.44003
Abstract: Piezo1 and Piezo2 belong to a family of mechanically-activated ion channels implicated in a wide range of physiological processes. Mechanical stimulation triggers Piezo channels to open, but their characteristic fast inactivation process results in rapid… read more here.
Keywords: helix; channels hydrophobic; inactivation; piezo channels ... See more keywords