CXCR4 Clustering Induced by Polymeric Nanothreads Impedes Cancer Cell Metastasis via PIEZO1‐Mediated Mechanotransduction
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202501072
Abstract: The way in which the antagonist binds to the target molecule affects the intervention of its downstream pathway. Previously, an antagonistic strategy for CXC chemokine receptor 4 (CXCR4) utilizing two polymeric nanothreads is developed that… read more here.
Keywords: piezo1 mediated; cxcr4 clustering; piezo1; polymeric nanothreads ... See more keywords
Low‐Frequency Ultrasound Sensitive Piezo1 Channels Regulate Keloid‐Related Characteristics of Fibroblasts
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202305489
Abstract: Keloids are benign fibroproliferative tumors that severely diminish the quality of life due to discomfort, dysfunction, and disfigurement. Recently, ultrasound technology as a noninvasive adjuvant therapy is developed to optimize treatment protocols. However, the biophysical… read more here.
Keywords: piezo1; ultrasound sensitive; piezo1 channels; frequency ultrasound ... See more keywords
PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202502052
Abstract: Current scientific consensus acknowledges mechanical stress, particularly compressive loading, as a critical contributor to the pathogenesis of vertebral growth plate disorders (VGPD), though the precise molecular mechanisms remain incompletely understood. This study establishes PIEZO1 as… read more here.
Keywords: vertebral growth; piezo1; growth plate; stress ... See more keywords
The Sirt1‐Piezo1 Axis Promotes Bone Formation and Repair in Mice
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202510103
Abstract: The mechanosensitive Piezo1 channel protein plays a pivotal role in promoting bone formation and repair; however, its underlying molecular mechanism(s) are poorly defined. Here this study shows that Sirt1 positively regulates Piezo1 expression and activity… read more here.
Keywords: repair; formation repair; bone formation; sirt1 ... See more keywords
Generation of Piezo1‐CreER transgenic mice for visualization and lineage tracing of mechanical force responsive cells in vivo
Sign Up to like & getrecommendations! Published in 2022 at "genesis"
DOI: 10.1002/dvg.23476
Abstract: Cells and tissues are exposed to a wide range of mechanical stimuli during development, tissue homeostasis, repair, and regeneration. Over the past few decades, mechanosensitive ion channels (MSCs), as force‐sensing integral membrane proteins, have attracted… read more here.
Keywords: generation piezo1; piezo1; force; cells vivo ... See more keywords
Inhibition of Piezo1 attenuates demyelination in the central nervous system
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23722
Abstract: Piezo1 is a mechanosensitive ion channel that facilitates the translation of extracellular mechanical cues to intracellular molecular signaling cascades through a process termed, mechanotransduction. In the central nervous system (CNS), mechanically gated ion channels are… read more here.
Keywords: demyelination; piezo1; nervous system; central nervous ... See more keywords
Regulation of PIEZO1 channels by lipids and the structural components of extracellular matrix/cell cytoskeleton
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31001
Abstract: PIEZO1 is a mechanosensitive channel widely presented in eukaryotic organisms. Although the PIEZO family was discovered in 2010, main questions related to the molecular structure as well as to specific activation mechanisms and regulating pathways… read more here.
Keywords: extracellular matrix; components extracellular; cytoskeleton; regulation piezo1 ... See more keywords
Bone Repairment via Mechanosensation of Piezo1 Using Wearable Pulsed Triboelectric Nanogenerator.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202201056
Abstract: Bone repair in real time is a challenging medical issue for elderly patients; this is mainly because aged bone marrow mesenchymal stem cells (BMSCs) possess limited osteogenesis potential and repair capacity. In this study, triboelectric… read more here.
Keywords: via mechanosensation; bone; triboelectric stimulation; mechanosensation piezo1 ... See more keywords
Inhibition of Piezo1/Ca2+/calpain signaling in the rat basal forebrain reverses sleep deprivation-induced fear memory impairments
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113594
Abstract: In this study, we tested the hypothesis that the Piezo1/Ca2+/calpain pathway of the basal forebrain (BF) modulates impaired fear conditioning caused by sleep deprivation. Adult male Wistar rats were subjected to 6h of total sleep… read more here.
Keywords: deprivation induced; sleep deprivation; piezo1; fear memory ... See more keywords
Identification of PIEZO1 polymorphisms for human bone mineral density.
Sign Up to like & getrecommendations! Published in 2020 at "Bone"
DOI: 10.1016/j.bone.2020.115247
Abstract: Bone mineral density (BMD) is a key indicator for diagnosis and treatment for osteoporosis; the reduction of BMD could increase the risk of osteoporotic fracture. It was very recently found that Piezo1 mediated mechanically evoked… read more here.
Keywords: bone mineral; piezo1; bmd; snp rs62048221 ... See more keywords
Piezo1 activates the NLRP3 inflammasome in nucleus pulposus cell-mediated by Ca2+/NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106681
Abstract: Studying and understanding the mechanism of inflammation in nucleus pulposus is the key to understand and prevent intervertebral disc degeneration. We propose a model of mechanical sensitive ion channel Piezo1 mediated inflammation of nucleus pulposus… read more here.
Keywords: ca2 pathway; nucleus pulposus; piezo1; pulposus cells ... See more keywords