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Published in 2022 at "genesis"
DOI: 10.1002/dvg.23476
Abstract: Cells and tissues are exposed to a wide range of mechanical stimuli during development, tissue homeostasis, repair, and regeneration. Over the past few decades, mechanosensitive ion channels (MSCs), as force‐sensing integral membrane proteins, have attracted…
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Keywords:
generation piezo1;
piezo1;
force;
cells vivo ... See more keywords
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Published in 2019 at "Glia"
DOI: 10.1002/glia.23722
Abstract: Piezo1 is a mechanosensitive ion channel that facilitates the translation of extracellular mechanical cues to intracellular molecular signaling cascades through a process termed, mechanotransduction. In the central nervous system (CNS), mechanically gated ion channels are…
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Keywords:
demyelination;
piezo1;
nervous system;
central nervous ... See more keywords
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Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31001
Abstract: PIEZO1 is a mechanosensitive channel widely presented in eukaryotic organisms. Although the PIEZO family was discovered in 2010, main questions related to the molecular structure as well as to specific activation mechanisms and regulating pathways…
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Keywords:
extracellular matrix;
components extracellular;
cytoskeleton;
regulation piezo1 ... See more keywords
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Published in 2022 at "Small"
DOI: 10.1002/smll.202201056
Abstract: Bone repair in real time is a challenging medical issue for elderly patients; this is mainly because aged bone marrow mesenchymal stem cells (BMSCs) possess limited osteogenesis potential and repair capacity. In this study, triboelectric…
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Keywords:
via mechanosensation;
bone;
triboelectric stimulation;
mechanosensation piezo1 ... See more keywords
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Published in 2022 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113594
Abstract: In this study, we tested the hypothesis that the Piezo1/Ca2+/calpain pathway of the basal forebrain (BF) modulates impaired fear conditioning caused by sleep deprivation. Adult male Wistar rats were subjected to 6h of total sleep…
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Keywords:
deprivation induced;
sleep deprivation;
piezo1;
fear memory ... See more keywords
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Published in 2020 at "Bone"
DOI: 10.1016/j.bone.2020.115247
Abstract: Bone mineral density (BMD) is a key indicator for diagnosis and treatment for osteoporosis; the reduction of BMD could increase the risk of osteoporotic fracture. It was very recently found that Piezo1 mediated mechanically evoked…
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Keywords:
bone mineral;
piezo1;
bmd;
snp rs62048221 ... See more keywords
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Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106681
Abstract: Studying and understanding the mechanism of inflammation in nucleus pulposus is the key to understand and prevent intervertebral disc degeneration. We propose a model of mechanical sensitive ion channel Piezo1 mediated inflammation of nucleus pulposus…
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Keywords:
ca2 pathway;
nucleus pulposus;
piezo1;
pulposus cells ... See more keywords
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Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118667
Abstract: AIM Diabetes is a high-risk factor for neurocognitive dysfunction. Diabetic acute hyperglycaemia accompanied by high osmotic pressure can induce immune cell dysfunction, but its mechanism of action in brain microglia remains unclear. This study aimed…
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Keywords:
piezo1;
hyperglycaemia;
acute hyperglycaemia;
jnk1 mtor ... See more keywords
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Published in 2020 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2020.110327
Abstract: Stroke is associated with high mortality and extremely high disability rate. Regulating ferroptosis seems to be a promising way to treat ischemic stroke. After stroke, vasogenic edema exerts a mechanical force on surrounding structures, which…
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Keywords:
ferroptosis regulation;
ferroptosis;
injury;
cerebral ischemia ... See more keywords
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Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00085
Abstract: Piezo1 is a member of the mechanosensitive piezo ion channel family, which transduces various mechanical stimulations into electrochemical signals. Piezo1 is closely implicated in different physiological processes ranging from erythrocyte volume homeostasis to lymphatic vessel…
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Keywords:
piezo1 promising;
ion channel;
piezo type;
ion ... See more keywords
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Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c00505
Abstract: Esophageal squamous cell carcinoma (ESCC) is a malignant epithelial cancer of the esophageal epithelium. Piezo-type mechanosensitive ion channel component 1 (Piezo1), an essential mechanosensitive protein, plays an important role in maintaining cell biological functions under…
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Keywords:
mechanosensitive protein;
cell;
piezo1 downregulation;
piezo1 ... See more keywords