Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-10153-8
Abstract: Macropinocytosis is a type of endocytosis accompanied by actin rearrangement-driven membrane deformation, such as lamellipodia formation and membrane ruffling, followed by the formation of large vesicles, macropinosomes. Ras-transformed cancer cells efficiently acquire exogenous amino acids… read more here.
Keywords: using yoda1; inhibits macropinocytosis; macropinocytosis; activation using ... See more keywords
Piezo1 activation augments sickling propensity and the adhesive properties of sickle red blood cells in a calcium-dependent manner.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of haematology"
DOI: 10.1111/bjh.18799
Abstract: Haemoglobin S polymerization in the red blood cells (RBCs) of individuals with sickle cell anaemia (SCA) can cause RBC sickling and cellular alterations. Piezo1 is a mechanosensitive protein that modulates intracellular calcium (Ca2+ ) influx,… read more here.
Keywords: red blood; sickling propensity; blood cells; piezo1 activation ... See more keywords
Abstract P067: Piezo1 Activation Inhibits Adipogenesis And Lipogenesis In Perivascular Adipose Tissue Preadipocytes
Sign Up to like & getrecommendations! Published in 2020 at "Hypertension"
DOI: 10.1161/hyp.76.suppl_1.p067
Abstract: In adipogenesis, perivascular adipose tissue (PVAT) preadipocytes turn into adipocytes. In non-PVAT preadipocytes, mechanical forces affect the commitment and lipogenic stages of adipogenesis. The mechanism may involve PIEZO1, a mechanosensor, that boosts differentiation of progenitor… read more here.
Keywords: piezo1 activation; piezo1; perivascular adipose; adipogenesis ... See more keywords
PIEZO1 activation delays erythroid differentiation of normal and hereditary xerocytosis-derived human progenitor cells
Sign Up to like & getrecommendations! Published in 2019 at "Haematologica"
DOI: 10.3324/haematol.2019.218503
Abstract: Hereditary xerocytosis is a dominantly inherited red cell membrane disorder caused in most cases by gain-of-function mutations in PIEZO1, encoding a mechanosensitive ion channel that translates a mechanic stimulus into calcium influx. We found that… read more here.
Keywords: piezo1 activation; progenitor cells; erythroid differentiation; piezo1 ... See more keywords
Ion channel Piezo1 activation promotes aerobic glycolysis in macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.976482
Abstract: Altered microenvironmental stiffness is a hallmark of inflammation. It is sensed by the mechanically activated cation channel Piezo1 in macrophages to induce subsequent immune responses. However, the mechanism by which the mechanosensitive signals shape the… read more here.
Keywords: promotes aerobic; activation promotes; piezo1 activation; aerobic glycolysis ... See more keywords
FM1-43 Dye Memorizes Piezo1 Activation in the Trigeminal Nociceptive System Implicated in Migraine Pain
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021688
Abstract: It has been proposed that mechanosensitive Piezo1 channels trigger migraine pain in trigeminal nociceptive neurons, but the mechanosensitivity of satellite glial cells (SGCs) supporting neuronal sensitization has not been tested before. Moreover, tools to monitor… read more here.
Keywords: piezo1 activation; trigeminal nociceptive; piezo1; migraine pain ... See more keywords
Prolonged Piezo1 Activation Induces Cardiac Arrhythmia
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DOI: 10.3390/ijms24076720
Abstract: The rhythmical nature of the cardiovascular system constantly generates dynamic mechanical forces. At the centre of this system is the heart, which must detect these changes and adjust its performance accordingly. Mechanoelectric feedback provides a… read more here.
Keywords: cardiac arrhythmias; piezo1 activation; mechanoelectric feedback; prolonged piezo1 ... See more keywords