Structural Modification and Pharmacological Evaluation of (Thiadiazol-2-yl)pyrazines as Novel Piezo1 Agonists for the Intervention of Disuse Osteoporosis.
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DOI: 10.1021/acs.jmedchem.4c02224
Abstract: Piezo1 plays a pivotal role in regulating bone remodeling and homeostasis and has emerged as a promising target for chemical intervention in disuse osteoporosis. Nevertheless, the development of small-molecule Piezo1 agonists is still in its… read more here.
Keywords: piezo1 agonists; structural modification; intervention disuse; piezo1 ... See more keywords