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Piezo1 channel‐mediated Ca2+ signaling inhibits lipopolysaccharide‐induced activation of the NF‐κB inflammatory signaling pathway and generation of TNF‐α and IL‐6 in microglial cells

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1 Published in 2022 at "Glia"

DOI: 10.1002/glia.24311

Abstract: Microglial cells are crucial in maintaining central nervous system (CNS) homeostasis and mediating CNS disease pathogenesis. Increasing evidence supports that alterations in the mechanical properties of CNS microenvironments influence glial cell phenotypes, but the mechanisms… read more here.

Keywords: activation; microglial cells; piezo1 channel; ca2 signaling ... See more keywords

Tubeimoside I Antagonizes Yoda1-Evoked Piezo1 Channel Activation

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0 Published in 2020 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2020.00768

Abstract: Piezo1, a mechanosensitive Ca2+-permeable non-selective cationic ion channel protein, is involved in a wide range of biological processes and plays crucial roles in vascular development. However, the pharmacology of this protein is in its infancy.… read more here.

Keywords: piezo1; piezo1 channel; yoda1; pharmacology ... See more keywords

Mechanical Stimulation-Induced Calcium Signaling by Piezo1 Channel Activation in Human Odontoblast Reduces Dentin Mineralization

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0 Published in 2021 at "Frontiers in Physiology"

DOI: 10.3389/fphys.2021.704518

Abstract: Odontoblasts play critical roles in dentin formation and sensory transduction following stimuli on the dentin surface. Exogenous stimuli to the dentin surface elicit dentinal sensitivity through the movement of fluids in dentinal tubules, resulting in… read more here.

Keywords: stimulation; human odontoblasts; piezo1 channel; mechanical stimulation ... See more keywords

Piezo1 Channel as a Potential Target for Hindering Cardiac Fibrotic Remodeling

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1 Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23158065

Abstract: Fibrotic tissues share many common features with neoplasms where there is an increased stiffness of the extracellular matrix (ECM). In this review, we present recent discoveries related to the role of the mechanosensitive ion channel… read more here.

Keywords: hindering cardiac; cardiac fibrotic; piezo1 channel; target hindering ... See more keywords