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1
Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2202269119
Abstract: Significance The mechanosensitive ion channel Piezo1 plays many important physiological functions. This essential ion channel is selectively activated by a synthetic small molecule called Yoda1. Despite current efforts to develop Yoda1 analogs with potential clinical…
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Keywords:
temperature;
footprint piezo1;
piezo1 channels;
energetic footprint ... See more keywords
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1
Published in 2022 at "British journal of pharmacology"
DOI: 10.1111/bph.15826
Abstract: BACKGROUND AND PURPOSE Salvianolic acid B (SalB) is effective for treating cardiovascular diseases. However, its therapeutic molecular mechanisms remain unclear. Mechanosensitive Piezo1 channels play important roles in vascular biology, although its pharmacological properties are poorly…
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Keywords:
cell;
piezo1 channels;
salvianolic acid;
salb inhibited ... See more keywords
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2
Published in 2023 at "Molecular pain"
DOI: 10.1177/17448069231174315
Abstract: Here, we present evidence showing Piezo1 protein expression in the primary sensory neurons (PSNs) and non-neuronal cells of rat peripheral nervous system. Using a knockdown/knockout validated antibody, we detected Piezo1 immunoreactivity (IR) in ∼60% of…
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Keywords:
piezo1 channels;
neuronal cells;
peripheral sensory;
piezo1 ... See more keywords
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0
Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0207309
Abstract: PIEZO1 and PIEZO2 are mechanosensitive channels (MSCs) important for cellular function and mutations in them lead to human disorders. We examined how functional heteromers form between subunits of PIEZO1 using the mutants E2117K, E2117D, and…
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Keywords:
piezo1 channels;
functional analyses;
piezo1;
human piezo1 ... See more keywords
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2
Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.976522
Abstract: Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease in the central nervous system (CNS). Its pathogenesis is quite complex: Accumulated evidence suggests that biochemical signals as well as mechanical stimuli play important…
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Keywords:
animal models;
piezo1 channels;
roles piezo1;
emerging roles ... See more keywords
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1
Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031370
Abstract: Mechanosensitive ion channels, Piezo1 and 2, are activated by pressure and involved in diverse physiological functions, including senses of touch and pain, proprioception and many more. Understanding their function is important for elucidating the mechanosensitive…
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Keywords:
trigeminal somatic;
piezo1 channels;
piezo1;
functional characterization ... See more keywords