Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels.
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DOI: 10.1016/j.celrep.2017.05.079
Abstract: Several cell types experience repetitive mechanical stimuli, including vein endothelial cells during pulsating blood flow, inner ear hair cells upon sound exposure, and skin cells and their innervating dorsal root ganglion (DRG) neurons when sweeping… read more here.
Keywords: mechanical stimuli; ion channels; frequency; repetitive mechanical ... See more keywords
The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis
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DOI: 10.3389/fcell.2022.885224
Abstract: Mechanical factors play critical roles in the pathogenesis of joint disorders like osteoarthritis (OA), a prevalent progressive degenerative joint disease that causes debilitating pain. Chondrocytes in the cartilage are responsible for extracellular matrix (ECM) turnover,… read more here.
Keywords: ion channels; piezo1 piezo2; piezo2 trpv4; mechanotransduction ... See more keywords
Mechanosensitive Piezo1 and Piezo2 ion channels in craniofacial development and dentistry: Recent advances and prospects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.1039714
Abstract: Mechanical forces play important roles in many biological processes and there is increasing interest and understanding of these roles. Mechanotransduction is the process by which mechanical stimuli are converted to biochemical signals through specific mechanisms,… read more here.
Keywords: piezo2; ion channels; mechanosensitive piezo1; piezo1 piezo2 ... See more keywords