Structure-guided examination of the mechanogating mechanism of PIEZO2
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1905985116
Abstract: Significance Aristotle’s five senses—sight, smell, taste, hearing, and touch—are crucial for the perception of and interaction with the environment. While the molecular machineries that detect visual, olfactory, gustatory, and auditory stimuli are well characterized, comparatively… read more here.
Keywords: mechanosensitivity; mechanogating mechanism; mechanism piezo2; piezo2 ... See more keywords
Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1101/2022.03.12.484097
Abstract: Osteoarthritis is characterized by mechanically driven pain but lacks adequate treatments. Here, the authors show that inhibiting a mechanically-sensitive ion channel expressed by nociceptors reduces pain behaviors in mouse models of joint pain. Non-opioid targets… read more here.
Keywords: piezo2; joint pain; osteoarthritis; pain ... See more keywords
Merkel cells and Meissner's corpuscles in human digital skin display Piezo2 immunoreactivity
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Anatomy"
DOI: 10.1111/joa.12688
Abstract: The transformation of mechanical energy into electrical signals is the first step in mechanotransduction in the peripheral sensory nervous system and relies on the presence of mechanically gated ion channels within specialized sensory organs called… read more here.
Keywords: merkel cells; immunoreactivity; merkel; meissner corpuscles ... See more keywords
Role of Piezo2 in mechanosensation by vagal esophageal afferent fibers
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734530
Abstract: The esophagus is densely innervated by extrinsic sensory afferents projected from the dorsal root and vagal ganglia capable of sensing mechanical and chemical stimuli. In particular a major subset of vagal afferents innervating the esophagus… read more here.
Keywords: vagal esophageal; afferent fibers; physiology; role piezo2 ... See more keywords
Electroacupuncture Attenuates Post-Inflammatory IBS-Associated Visceral and Somatic Hypersensitivity and Correlates With the Regulatory Mechanism of Epac1–Piezo2 Axis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.918652
Abstract: Electroacupuncture (EA) is considered to have a therapeutic effect in the relief of irritable bowel syndrome (IBS)-associated visceral hypersensitivity via the reduction of the level of 5‐hydroxytryptamine (5‐HT) and 5-HT3 receptors (5-HT3R). However, whether Epac1/Piezo2,… read more here.
Keywords: ibs; somatic hypersensitivity; epac1 piezo2; piezo2 ... See more keywords
A pan-cancer analysis reveals the genetic alterations and immunotherapy of Piezo2 in human cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.918977
Abstract: Background: Piezo2 is a transmembrane-spanning ion channel protein implicated in multiple physiological processes, including cell proliferation and angiogenesis in many cell types. However, Piezo2 was recognized as representing a double-edged sword in terms of tumor… read more here.
Keywords: pan cancer; piezo2 expression; analysis; piezo2 ... See more keywords
Mechanosensitive Piezo1 and Piezo2 ion channels in craniofacial development and dentistry: Recent advances and prospects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.1039714
Abstract: Mechanical forces play important roles in many biological processes and there is increasing interest and understanding of these roles. Mechanotransduction is the process by which mechanical stimuli are converted to biochemical signals through specific mechanisms,… read more here.
Keywords: piezo2; ion channels; mechanosensitive piezo1; piezo1 piezo2 ... See more keywords
Mechano-Sensing Channel PIEZO2 Enhances Invasive Phenotype in Triple-Negative Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179909
Abstract: Background: Mechanically gated PIEZO channels lead to an influx of cations, activation of additional Ca2+ channels, and cell depolarization. This study aimed to investigate PIEZO2’s role in breast cancer. Methods: The clinical relevance of PIEZO2… read more here.
Keywords: breast cancer; piezo2; piezo2 overexpressed; expression ... See more keywords
Merkel Cell Carcinoma Display PIEZO2 Immunoreactivity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12060894
Abstract: As an essential component of mechano-gated ion channels, critically required for mechanotransduction in mammalian cells, PIEZO2 is known to be characteristically expressed by Merkel cells in human skin. Here, we immunohistochemically investigated the occurrence of… read more here.
Keywords: piezo2; cell carcinoma; merkel; merkel cell ... See more keywords