The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis
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DOI: 10.3389/fcell.2022.885224
Abstract: Mechanical factors play critical roles in the pathogenesis of joint disorders like osteoarthritis (OA), a prevalent progressive degenerative joint disease that causes debilitating pain. Chondrocytes in the cartilage are responsible for extracellular matrix (ECM) turnover,… read more here.
Keywords: ion channels; piezo1 piezo2; piezo2 trpv4; mechanotransduction ... See more keywords