Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13414-9
Abstract: Pif1 plays multiple roles in maintaining genome stability and preferentially unwinds forked dsDNA, but the mechanism by which Pif1 unwinds forked dsDNA remains elusive. Here we report the structure of Bacteroides sp Pif1 (BaPif1) in… read more here.
Keywords: dsdna two; forked dsdna; unwinds forked; bapif1 ... See more keywords
Structure and function of Pif1 helicase.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Society transactions"
DOI: 10.1042/bst20170096
Abstract: Pif1 family helicases have multiple roles in the maintenance of nuclear and mitochondrial DNA in eukaryotes. Saccharomyces cerevisiae Pif1 is involved in replication through barriers to replication, such as G-quadruplexes and protein blocks, and reduces… read more here.
Keywords: function pif1; helicase; pif1 helicase; pif1 ... See more keywords
The Pif1 helicase is actively inhibited during meiotic recombination which restrains gene conversion tract length
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DOI: 10.1093/nar/gkab232
Abstract: Abstract Meiotic recombination ensures proper chromosome segregation to form viable gametes and results in gene conversions events between homologs. Conversion tracts are shorter in meiosis than in mitotically dividing cells. This results at least in… read more here.
Keywords: conversion; helicase; meiotic recombination; recombination ... See more keywords
Up-regulated PIF1 predicts poor clinical outcomes and correlates with low immune infiltrates in clear cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1058040
Abstract: Background: Petite Integration Factor 1 (PIF1) is a multifunctional helicase and DNA processing enzyme that plays an important role in the process of several cancer types. However, the relationship between clear cell renal cell carcinoma… read more here.
Keywords: cell; ccrcc; expression pif1; pif1 ... See more keywords