P53 inhibitor pifithrin‐α inhibits ropivacaine‐induced neuronal apoptosis via the mitochondrial apoptosis pathway
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22822
Abstract: The neurotoxicity of local anesthetics (LAs) has attracted more and more attention, However, they lack preventive and therapeutic measures. Many studies have shown that apoptosis plays an important role in the process of LA‐induced neurotoxicity.… read more here.
Keywords: apoptosis; p53 inhibitor; pft; pifithrin ... See more keywords
Pifithrin-α ameliorates glycerol induced rhabdomyolysis and acute kidney injury by reducing p53 activation
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2048857
Abstract: Abstract Objectives Rhabdomyolysis is a series of symptoms caused by the dissolution of striped muscle, and acute kidney injury (AKI) is a potential complication of severe rhabdomyolysis. The underlying causes of AKI are remarkably complex… read more here.
Keywords: rhabdomyolysis; glycerol; group; pifithrin ... See more keywords