Hybrid zoo: Introducing pig–human embryos and a rat–mouse
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature.2017.21378
Abstract: Chimaeras could pave the way for growing human organs in other animals. read more here.
Keywords: hybrid zoo; human embryos; zoo introducing; pig human ... See more keywords
Physiologic considerations of pig-to-human kidney xenotransplantation
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000858
Abstract: Purpose of review The greatest challenge facing end-stage kidney disease (ESKD) patients is the scarcity of transplantable organs. Advances in genetic engineering that mitigate xenogeneic immune responses have made transplantation across species a potentially viable… read more here.
Keywords: pig human; human kidney; physiologic considerations; considerations pig ... See more keywords
ETph: enhancers and their targets in pig and human database.
Sign Up to like & getrecommendations! Published in 2019 at "Animal genetics"
DOI: 10.1111/age.12893
Abstract: Enhancers, as the genomic non-coding sequences, play a key role in the activation of gene expression. They have been widely identified in the human genome. Pig is an important biomedical model for human health. Few… read more here.
Keywords: pig human; etph enhancers; targets pig; enhancers targets ... See more keywords
Pig‐to‐human heart transplantation: Who goes first?
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Transplantation"
DOI: 10.1111/ajt.15916
Abstract: Cardiac xenotransplantation has recently taken an important step towards clinical reality. In anticipation of the “first‐in‐human” heart xenotransplantation trial, we propose a set of patient characteristics that define potential candidates. Our premise is that, to… read more here.
Keywords: human heart; heart; pig human; heart transplantation ... See more keywords
Developing pig-to-human organ transplants
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abo7935
Abstract: Recent advances raise hope for a promising solution to the transplant organ shortage Over 100,000 people in the US are currently waiting for organ transplants. Because the human organ donor pool cannot keep pace with… read more here.
Keywords: organ transplants; pig human; physiology; developing pig ... See more keywords
The Role of NK Cells in Pig-to-Human Xenotransplantation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Immunology Research"
DOI: 10.1155/2017/4627384
Abstract: Recruitment of human NK cells to porcine tissues has been demonstrated in pig organs perfused ex vivo with human blood in the early 1990s. Subsequently, the molecular mechanisms leading to adhesion and cytotoxicity in human… read more here.
Keywords: cells pig; pig human; role cells; role ... See more keywords