A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.03.005
Abstract: Huntington's disease (HD) is characterized by preferential loss of the medium spiny neurons in the striatum. Using CRISPR/Cas9 and somatic nuclear transfer technology, we established a knockin (KI) pig model of HD that endogenously expresses… read more here.
Keywords: selective neurodegeneration; huntington disease; pig model; knockin pig ... See more keywords
AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2020.02.041
Abstract: BACKGROUND miR-21 is a central regulator of cardiac fibrosis, and its inhibition in small-animal models has been shown to be an effective antifibrotic strategy in various organs, including the heart. Effective delivery of therapeutic antisense… read more here.
Keywords: antimir; pig model; model; ischemia reperfusion ... See more keywords
Fiber-rich foods affected gut bacterial community and short-chain fatty acids production in pig model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.04.009
Abstract: Abstract This study aimed to explore effects of different fiber-rich foods on bacterial community and their metabolites in pig model. Thirty-six pigs were allotted to 6 dietary treatments including corn bran (CB), wheat bran (WB),… read more here.
Keywords: bacterial community; production; pig model; fiber rich ... See more keywords
Protective efficacy of a lipid antigen vaccine in a guinea pig model of tuberculosis.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.01.079
Abstract: The bacillus Calmette Guérin (BCG) vaccine, the only licensed vaccine against TB, displays partial and variable efficacy, thus making the exploitation of novel vaccination strategies a major priority. Most of the current vaccines in pre-clinical… read more here.
Keywords: guinea pig; pig model; efficacy; tuberculosis ... See more keywords
A pig model of Huntington’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Nature Medicine"
DOI: 10.1038/s41591-018-0119-2
Abstract: Knock-in of the huntingtin gene in pigs recreates key features of Huntington’s disease. Huntington’s disease is a severe neurodegenerative monogenetic disease that results in age-dependent selective neuronal loss in affected individuals—a feature that cannot be… read more here.
Keywords: model huntington; huntington disease; pig model; disease ... See more keywords
Gut microbiome contributions to altered metabolism in a pig model of undernutrition
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2024446118
Abstract: Significance Employing an intergenerational model of diet restriction (DR) that reduces weight gain, we identify differences in carbohydrate metabolic enzyme gene content of DR versus full-fed (FF) pig gut microbiomes as animals experienced a phased-feeding… read more here.
Keywords: pig; metabolism; pig model; gut microbiome ... See more keywords
Can A Recently Developed Pig Model Be Used for In Vivo Metabolism Studies of 7-Azaindole Derived Synthetic Cannabinoids? A Study Using 5F-MDMB-P7AICA.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of analytical toxicology"
DOI: 10.1093/jat/bkaa122
Abstract: New psychoactive substances (NPS), especially synthetic cannabinoids (SC) remain a public health concern. Due to ethical reasons, systematic controlled human studies to elucidate their toxicodynamics and/or toxicokinetics are usually not possible. However, such knowledge is… read more here.
Keywords: vivo metabolism; pig; metabolism studies; pig model ... See more keywords
Uropathogenic Escherichia coli can cause cystitis at extremely low inocula in a pig model.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medical microbiology"
DOI: 10.1099/jmm.0.001537
Abstract: Urinary tract infection (UTI) is one of the most common bacterial infections worldwide. Experimental models that accurately reflect the high susceptibility to UTI in humans have, however, been lacking. This situation has limited detailed research… read more here.
Keywords: urinary tract; uropathogenic escherichia; escherichia coli; pig model ... See more keywords
Toxicity study in a pig model of intraperitoneal collagenase as an “enzymatic scalpel” directed to break stroma in order to generate a new perspective for peritoneal carcinomatosis approach: an experimental research
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Surgical Oncology"
DOI: 10.1186/s12957-022-02524-2
Abstract: Background This study aimed to measure the toxicity resulting from collagenase administration to the peritoneal cavity in a pig model as a preliminary step to break down the stroma surrounding tumors. Methods Eight pigs were… read more here.
Keywords: study; peritoneal; collagenase; pig model ... See more keywords
Standardized guinea pig model for Q fever vaccine reactogenicity
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0205882
Abstract: Historically, vaccination with Coxiella burnetii whole cell vaccines has induced hypersensitivity reactions in humans and animals that have had prior exposure to the pathogen as a result of infection or vaccination. Intradermal skin testing is… read more here.
Keywords: guinea pig; pig model; exposure; reactogenicity ... See more keywords
Duration of protection from live attenuated vs. sub unit HSV-2 vaccines in the guinea pig model of genital herpes: Reassessing efficacy using endpoints from clinical trials
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0213401
Abstract: Background Although herpes simplex viruses (HSV) are a major target for vaccine development no vaccine is currently licensed. Methods A live attenuated HSV virus vaccine, VC2 was compared to a subunit HSV vaccine, glycoprotein D… read more here.
Keywords: guinea pig; protection; pig model; live attenuated ... See more keywords