Determination of Phosphodiesterase Inhibitors Tadalafil, Roflumilast and Roflumilast N-Oxide Using LC-MS in Guinea Pig Plasma.
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DOI: 10.1093/chromsci/bmy072
Abstract: Phosphodiesterases are known as a super-family of 11 isoenzymes, which can exert various functions based on their organ distribution. In this work, a rapid and sensitive ultra-high performance liquid chromatography-tandem mass spectrometry method was developed… read more here.
Keywords: guinea; guinea pig; phosphodiesterase; roflumilast ... See more keywords