Pacing Dynamics Determines the Arrhythmogenic Mechanism of the CPVT2-Causing CASQ2G112+5X Mutation in a Guinea Pig Ventricular Myocyte Computational Model
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes14010023
Abstract: Calsequestrin Type 2 (CASQ2) is a high-capacity, low-affinity, Ca2+-binding protein expressed in the sarcoplasmic reticulum (SR) of the cardiac myocyte. Mutations in CASQ2 have been linked to the arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT2) that… read more here.
Keywords: myocyte; computational model; pig ventricular; mutation ... See more keywords